IPLab:Lab 7:Adenoma: Difference between revisions - Pathology Education Instructional Resource

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This 80-year-old white female's death came as the result of cardiopulmonary disease -- hypertension, coronary artery disease, pulmonary emphysema and cardiac hypertrophy.

~~== Autopsy Findings ==~~

During a routine postmortem examination, this patient's thyroid gland was found to be nodular. The right lobe contained several colloid nodules. Located in the left lobe was a 2-cm well-circumscribed mass.

== Images ==

File:~~IPLab7Adenoma1~~.jpg|This is a low-power photomicrograph of a nodule found in the thyroid of this case. Note that the mass is well-circumscribed and there is a sharp line of demarcation between the mass and the adjacent thyroid tissue (arrows).

File:IPLab7Adenoma1b.jpg|This is a low-power photomicrograph of a nodule found in the thyroid of this case. Note that the mass is well-circumscribed and there is a sharp line of demarcation between the mass and the adjacent thyroid tissue (arrows).

File:~~IPLab7Adenoma2~~.jpg|This is a higher-power view of the border between the tumor mass and the adjacent thyroid tissue. Note that the mass has ~~compressed the adjacent normal thyroid tissue~~ (arrow). Also note the different morphology between the adenoma (very cellular, dense follicles~~, little or no colloid~~) and the adjacent normal thyroid (larger follicles, colloid).

File:IPLab7Adenoma2b.jpg|This is a higher-power view of the border between the tumor mass and the adjacent thyroid tissue. Note that the mass has a capsule (arrow). Also note the different morphology between the adenoma on the bottom (very cellular, dense follicles) and the adjacent normal thyroid (larger follicles, colloid).

File:~~IPLab7Adenoma3~~.jpg|This is another higher-power photomicrograph of the adenoma (~~left~~) and the adjacent thyroid tissue (~~right~~). Note the ~~compression of the adjacent normal thyroid and the difference in morphology between the adenoma and the thyroid.~~

File:IPLab7Adenoma3b.jpg|This is another higher-power photomicrograph of the adenoma (bottom) and the adjacent thyroid tissue (top). Note the capsule(*) separating the adenoma from the adjacent normal thyroid tissue.

~~File:IPLab7Adenoma4.jpg|This photomicrograph demonstrates the densely packed follicular pattern in the adenoma~~ (~~left~~) ~~and~~ the ~~larger colloid-filled follicles of~~ the normal thyroid ~~(right). An area of compressed thyroid is present adjacent to the adenoma (arrows)~~.

File:IPLab7Adenoma4b.jpg|This is a photomicrograph of the adenoma. Note that the follicular architecture is well developed throughout this section.

File:~~IPLab7Adenoma5~~.jpg|This is a photomicrograph of an adenoma. Note that the follicular architecture is well developed ~~and more or less uniform~~ throughout this section.

~~File:IPLab7Adenoma6.jpg|This high-power photomicrograph demonstrates the relatively normal cellular morphology of this follicular adenoma~~.

</gallery>

== Virtual Microscopy ==

<peir-vm>IPLab7Adenoma</peir-vm>

== Study Questions ==

Line 27:

== Additional Resources ==

=== Reference ===

* [http://emedicine.medscape.com/article/850823-overview eMedicine Medical Library: Evaluation of Solitary Thyroid Nodule]

* [http://emedicine.medscape.com/article/127491-overview eMedicine Medical Library: Thyroid Nodule]

=== Journal Articles ===

* Tonacchera M, Vitti P, Agretti P, Ceccarini G, Perri A, Cavaliere R, Mazzi B, Naccarato AG, Viacava P, Miccoli P, Pinchera A, Chiovato L. [http://www.ncbi.nlm.nih.gov/pubmed/10566665 Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms]. ''J Clin Endocrinol Metab'' 1999 Nov;84(11):4155-8.

=== Images ===

* [{{SERVER}}/library/index.php?/tags/140-thyroid PEIR Digital Library: Thyroid Images]

* [http://library.med.utah.edu/WebPath/ENDOHTML/ENDOIDX.html WebPath: Endocrine Pathology]

== Related IPLab Cases ==

* [[IPLab:Lab 6:Graves Disease|Lab 6: Thyroid: Graves Disease]]

[[Category: IPLab:Lab 7]]

@@ Line 2: / Line 2: @@
 This 80-year-old white female's death came as the result of cardiopulmonary disease -- hypertension, coronary artery disease, pulmonary emphysema and cardiac hypertrophy.
-== Autopsy Findings ==
+During a routine postmortem examination, this patient's thyroid gland was found to be nodular. The right lobe contained several colloid nodules. Located in the left lobe was a 2-cm well-circumscribed mass.
-During a routine postmortem examination, this patient's thyroid gland was found to be nodular. The right lobe contained several colloid nodules. Located in the left lobe was a 2-cm well-circumscribed mass.
 == Images ==
 <gallery heights="250px" widths="250px">
-File:IPLab7Adenoma1.jpg|This is a low-power photomicrograph of a nodule found in the thyroid of this case. Note that the mass is well-circumscribed and there is a sharp line of demarcation between the mass and the adjacent thyroid tissue (arrows).
+File:IPLab7Adenoma1b.jpg|This is a low-power photomicrograph of a nodule found in the thyroid of this case. Note that the mass is well-circumscribed and there is a sharp line of demarcation between the mass and the adjacent thyroid tissue (arrows).
-File:IPLab7Adenoma2.jpg|This is a higher-power view of the border between the tumor mass and the adjacent thyroid tissue. Note that the mass has compressed the adjacent normal thyroid tissue (arrow). Also note the different morphology between the adenoma (very cellular, dense follicles, little or no colloid) and the adjacent normal thyroid (larger follicles, colloid).
+File:IPLab7Adenoma2b.jpg|This is a higher-power view of the border between the tumor mass and the adjacent thyroid tissue. Note that the mass has a  capsule (arrow). Also note the different morphology between the adenoma on the bottom (very cellular, dense follicles) and the adjacent normal thyroid (larger follicles, colloid).
-File:IPLab7Adenoma3.jpg|This is another higher-power photomicrograph of the adenoma (left) and the adjacent thyroid tissue (right). Note the compression of the adjacent normal thyroid and the difference in morphology between the adenoma and the thyroid.
+File:IPLab7Adenoma3b.jpg|This is another higher-power photomicrograph of the adenoma (bottom) and the adjacent thyroid tissue (top). Note the capsule(*) separating the adenoma from the adjacent normal thyroid tissue.
-File:IPLab7Adenoma4.jpg|This photomicrograph demonstrates the densely packed follicular pattern in the adenoma (left) and the larger colloid-filled follicles of the normal thyroid (right). An area of compressed thyroid is present adjacent to the adenoma (arrows).
+File:IPLab7Adenoma4b.jpg|This is a photomicrograph of the adenoma. Note that the follicular architecture is well developed throughout this section.
-File:IPLab7Adenoma5.jpg|This is a photomicrograph of an adenoma. Note that the follicular architecture is well developed and more or less uniform throughout this section.
-File:IPLab7Adenoma6.jpg|This high-power photomicrograph demonstrates the relatively normal cellular morphology of this follicular adenoma.
 </gallery>
+== Virtual Microscopy ==
+<peir-vm>IPLab7Adenoma</peir-vm>
 == Study Questions ==
@@ Line 27: / Line 27: @@
 == Additional Resources ==
 === Reference ===
+* [http://emedicine.medscape.com/article/850823-overview eMedicine Medical Library: Evaluation of Solitary Thyroid Nodule]
+* [http://emedicine.medscape.com/article/127491-overview eMedicine Medical Library: Thyroid Nodule]
 === Journal Articles ===
+* Tonacchera M, Vitti P, Agretti P, Ceccarini G, Perri A, Cavaliere R, Mazzi B, Naccarato AG, Viacava P, Miccoli P, Pinchera A, Chiovato L.  [http://www.ncbi.nlm.nih.gov/pubmed/10566665 Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms].  ''J Clin Endocrinol Metab'' 1999 Nov;84(11):4155-8.
 === Images ===
+* [{{SERVER}}/library/index.php?/tags/140-thyroid PEIR Digital Library: Thyroid Images]
+* [http://library.med.utah.edu/WebPath/ENDOHTML/ENDOIDX.html WebPath: Endocrine Pathology]
 == Related IPLab Cases ==
+* [[IPLab:Lab 6:Graves Disease|Lab 6: Thyroid: Graves Disease]]
 {{IPLab 7}}
 [[Category: IPLab:Lab 7]]