IPLab:Lab 7:Lip SCC: Difference between revisions - Pathology Education Instructional Resource

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This 63-year-old white male had recurrent thickening and scaling of the lower lip for two years. In recent months, it had undergone ulceration and progressive enlargement. The lesion was excised by a wedge resection.

~~== Autopsy Findings ==~~

The biopsy specimen was triangular in shape; the upper part was covered by mucosa and the lower part by skin. At the junction of the mucosa and skin there was a 2 x 1.4 cm oval shaped superficial lesion which was flat, firm, and had raised borders. The base was orange.

The specimen was triangular in shape; the upper part was covered by mucosa and the lower part by skin. At the junction of the mucosa and skin there was a 2 x 1.4 cm oval shaped superficial lesion which was flat, firm, and had raised borders. The base was orange.

== Images ==

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=== Journal Articles ===

* Guenthner ST, Hurwitz RM, Buckel LJ, Gray HR. [http://www.ncbi.nlm.nih.gov/pubmed/10459120 Cutaneous squamous cell carcinomas consistently show histologic evidence of in situ changes: a clinicopathologic correlation]. ''J Am Acad Dermatol'' 1999 Sep;41(3 Pt 1):443-8.

* Ling S, Hu Z, Yang Z, Yang F, Li Y, Lin P, Chen K, Dong L, Cao L, Tao Y, Hao L, Chen Q, Gong Q, Wu D, Li W, Zhao W, Tian X, Hao C,Hungate EA, Catenacci DV, Hudson RR, Li WH, Lu X, Wu CI. [http://www.pnas.org/content/112/47/E6496.full.pdf Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.]. ''Proc Natl Acad Sci U S A'' 2015 Nov 24;112(47):E6496-505.

=== Images ===

@@ Line 2: / Line 2: @@
 This 63-year-old white male had recurrent thickening and scaling of the lower lip for two years. In recent months, it had undergone ulceration and progressive enlargement. The lesion was excised by a wedge resection.
-== Autopsy Findings ==
+The biopsy specimen was triangular in shape; the upper part was covered by mucosa and the lower part by skin. At the junction of the mucosa and skin there was a 2 x 1.4 cm oval shaped superficial lesion which was flat, firm, and had raised borders. The base was orange.
-The specimen was triangular in shape; the upper part was covered by mucosa and the lower part by skin. At the junction of the mucosa and skin there was a 2 x 1.4 cm oval shaped superficial lesion which was flat, firm, and had raised borders. The base was orange.
 == Images ==
@@ Line 33: / Line 32: @@
 === Journal Articles ===
 * Guenthner ST, Hurwitz RM, Buckel LJ, Gray HR.  [http://www.ncbi.nlm.nih.gov/pubmed/10459120 Cutaneous squamous cell carcinomas consistently show histologic evidence of in situ changes: a clinicopathologic correlation].  ''J Am Acad Dermatol'' 1999 Sep;41(3 Pt 1):443-8.
+* Ling S, Hu Z, Yang Z, Yang F, Li Y, Lin P, Chen K, Dong L, Cao L, Tao Y, Hao L, Chen Q, Gong Q, Wu D, Li W, Zhao W, Tian X, Hao C,Hungate EA, Catenacci DV, Hudson RR, Li WH, Lu X, Wu CI.   [http://www.pnas.org/content/112/47/E6496.full.pdf Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.].  ''Proc Natl Acad Sci U S A'' 2015 Nov 24;112(47):E6496-505.
 === Images ===