IPLab:Lab 6:Senile Amyloidosis
This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.
The heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.
Atrial natriuretic peptide.
Eighth and ninth decades.
Senile amyloid deposits also occur in the lungs, pancreas, and spleen. Senile cerebral amyloidosis occurs due to deposition of A beta 2 protein in cerebral blood vessels and in senile plaques of Alzheimer's disease patients.
- eMedicine Medical Library: Amyloidosis
- eMedicine Medical Library: Transthyretin-Related Amyloidosis
- Merck Manual: Amyloidosis
- Moyssakis I, Triposkiadis F, Rallidis L, Hawkins P, Kyriakidis M, Nihoyannopoulos P. Echocardiographic features of primary, secondary and familial amyloidosis. Eur J Clin Invest 1999 Jun;29(6):484-9.
Osteomyelitis is usually a pyogenic bacteria induced infection/inflammation of bone.
Normal blood glucose levels should be 70 to 100 mg/dL.
A normal bicarbonate level would be 23 to 29 mmol/L (critical level: <10 or >35 mmol/L).
A normal heart weighs 300 grams (range: 270 to 360 grams).