IPLab:Lab 13:Cystic Fibrosis

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Clinical Summary[edit]

This white female infant was the product of an uncomplicated term delivery, though meconium staining was noted at birth. During the first day post-partum, the infant's abdomen became progressively distended and a meconium ileus was suspected. Surgery confirmed the presence of a meconium ileus and a section of perforated atretic jejunum proximal to the ileus was resected. Eight days later, the patient's condition had deteriorated. A second operation revealed a segment of necrotic bowel, which was removed. Subsequently the infant's pulmonary function deteriorated and she required frequent suctioning. She developed repeated episodes of pneumonia (E. coli and Pseudomonas grew out on cultures) complicated by atelectasis secondary to pneumothorax. The patient died at 25-days-of-age in respiratory failure.

Autopsy Findings[edit]

Bilateral, extensive organizing bronchopneumonia was present with evidence of a pneumothorax and atelectasis. There were significant changes in the pancreas consistent with cystic fibrosis as well as involvement of the small intestine and changes related to the surgical procedures.


Virtual Microscopy[edit]



Study Questions[edit]

Additional Resources[edit]


Journal Articles[edit]


Meconium is a dark-green mucilaginous mixture of intestinal secretions and amniotic fluid which is found in the intestine of a full-term fetus. Meconium-stained amniotic fluid, found at delivery, may be an indication of perinatal asphyxia.

Meconium ileus occurs when abnormally viscid meconium completely obstructs the ileum of a newborn.

In alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents.

Atelectasis is the collapse of an airway and lung, regardless of the cause, resulting in reduced or absent gas exchange.

A pneumothorax is an accumulation of gas in the pleural space.

Cirrhosis is a liver disease characterized by necrosis, fibrosis, loss of normal liver architecture, and hyperplastic nodules.