Difference between revisions of "IPLab:Lab 6:Senile Amyloidosis"

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This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.
 
This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.
  
== Autopsy Findings ==
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At autopsy the heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.
The heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.  
 
  
 
== Images ==
 
== Images ==
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File:IPLab6SenileAmyloidosis5.jpg|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.  
 
File:IPLab6SenileAmyloidosis5.jpg|This is a special stain for amyloid (Luxol PAS) demonstrating the amyloid (1) and fibrosis (2) in the myocardium. The amyloid is darker purple/magenta and tends to be more amorphous. The fibrosis is pink and more fibrillar.  
 
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== Virtual Microscopy ==
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<peir-vm>IPLab6SenileAmyloidosis</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==

Latest revision as of 00:23, 9 July 2020

Clinical Summary[edit]

This 87-year-old black male diabetic was admitted for amputation of the lower extremity involved by atherosclerotic gangrene and osteomyelitis. Following amputation, the patient's course was one of progressive deterioration. Laboratory studies immediately prior to death revealed a blood glucose of 840 mg/dL and a serum CO2 (bicarbonate) of 8.5 mmol/L.

At autopsy the heart weighed 540 grams. The endocardial surface of both atria presented a mottled gray-red and gray-white appearance. Multiple sections through the myocardium revealed a marked 'pallor' of the muscle.

Images[edit]

Virtual Microscopy[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

Osteomyelitis is usually a pyogenic bacteria induced infection/inflammation of bone.

Normal blood glucose levels should be 70 to 100 mg/dL.

A normal bicarbonate level would be 23 to 29 mmol/L (critical level: <10 or >35 mmol/L).

A normal heart weighs 300 grams (range: 270 to 360 grams).