IPLab:Lab 6:Glomerulonephritis

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Clinical Summary[edit]

This 27-year-old male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a markedly elevated BUN and creatinine. He underwent bilateral nephrectomy and was placed on the transplant list.

On examination the kidneys were similar in appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.

Autopsy Findings[edit]

The left (97 grams) and right (88 grams) kidneys were of similar appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.

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Related IPLab Cases[edit]

A normal alkaline phosphatase is 39 to 117 U/L.

These tests are measures of kidney function. High levels mean low function.

A normal kidney weighs 157 grams (range: 115 to 220 grams).

A normal kidney weighs 157 grams (range: 115 to 220 grams).

Oliguria is the occurrence of decreased urine output.

Hematuria is the presence of blood in the urine.