IPLab:Lab 6:Acute Rejection

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Clinical Summary[edit]

This 34-year-old male with end-stage chronic glomerulonephritis had been receiving hemodialysis for 4 months when he received a living related-donor transplantation from his mother. The transplant was successfully with no complications. However, eight days later, transplant rejection necessitated removal of the transplanted kidney. After the nephrectomy, the patient did well and was returned to hemodialysis.

The rejected kidney was edematous and the pale tan-brown cortex was irregularly red-mottled. Upon sectioning the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis had generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.

Autopsy Findings[edit]

The kidney weighed 240 grams and was edematous. The capsule stripped with ease to reveal a pale tan-brown cortex which was irregularly red-mottled. Upon sectioning, the cortical band was ill-defined, and the corticomedullary junction was not well-demarcated. The renal papillae were edematous and the renal pelvis displayed generalized petechial hemorrhages which extended through the 7-cm segment of ureter to a diffusely hemorrhagic terminal portion.

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Related IPLab Cases[edit]

A normal kidney weighs 157 grams (range: 115 to 220 grams).

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.