IPLab:Lab 13:Wilms Tumor

Images

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  This is a gross photograph of a bladder (1) to which are attached a normal kidney (2) and a kidney with Wilms' tumor (3). A large mass extends from the superior pole of the affected kidney. The renal capsule can be seen extending around this tumor.

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  This is a closer view of the kidney with Wilms' tumor (arrows).

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  This is a gross photograph of lung from this case demonstrating the metastatic tumor nodule (arrow).

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  This lowest-power view shows the tumor itself; no tissue is present that can be readily identified as normal kidney. There does appear to be a capsule surrounding the tumor. Eosinophilic bands are seen surrounding basophilic islands of cells. These correspond to the two types of tissue in this tumor--the basophilic cellular component termed "blastema" can be distinguished from less cellular eosinophilic areas.

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  This low-power photomicrograph of tumor shows the two cell types making up this neoplasm. The basophilic cellular component termed "blastema" (1) can be distinguished from less cellular eosinophilic areas with fibroblast-like cells (2).

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  This medium-power photomicrograph of tumor shows again the two cell types making up this neoplasm. There are regions within the blastema where the cells form glands or "tubules" (arrows).

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  This is another medium-power photomicrograph of the tumor. It demonstrates again the two cell types making up this neoplasm. The glands or "tubules" within the blastema are better developed in this section (arrows).

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  This is a high-power photomicrograph of "tubule" formation within the blastema (arrows).

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  This high-power photomicrograph demonstrates tubule formation within the blastema. Note the numerous mitotic figures (arrows).

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  This high-power photomicrograph shows the differences in cell morphology between the blastema (1) and the fibroblast type cells (2).