Difference between revisions of "IPLab:Lab 5:Neurofibromatosis"

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(Autopsy Findings)
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== Images ==
 
== Images ==
 
<gallery heights="250px" widths="250px">
 
<gallery heights="250px" widths="250px">
File:IPLab5Neurofibromatosis1.jpg|This photograph, taken at autopsy, demonstrates the distribution of neurofibromas on the skin of this patient.  
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File:IPLab5Neurofibromatosis1b.JPG|This photograph, taken at autopsy, demonstrates the distribution of neurofibromas on the skin of this patient.  
File:IPLab5Neurofibromatosis2.jpg|This is another view taken at autopsy demonstrating the neurofibromas. Some lesions can be seen as subcutaneous swellings (arrow) and others form pedunculated masses. Most are hyperpigmented.  
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File:IPLab5Neurofibromatosis2b.JPG|This is another view taken at autopsy demonstrating the neurofibromas. Some lesions can be seen as subcutaneous swellings (arrow) and others form pedunculated masses. Most are hyperpigmented.  
File:IPLab5Neurofibromatosis3.jpg|This is a closer view of neurofibromas on the skin.  
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File:IPLab5Neurofibromatosis3b.JPG|This is a closer view of neurofibromas on the skin.  
 
File:IPLab5Neurofibromatosis4.jpg|This is a low-power photomicrograph of a subcutaneous neurofibroma (1). Note the increased pigmentation in the skin (2).  
 
File:IPLab5Neurofibromatosis4.jpg|This is a low-power photomicrograph of a subcutaneous neurofibroma (1). Note the increased pigmentation in the skin (2).  
 
File:IPLab5Neurofibromatosis5.jpg|This is a higher-power photomicrograph of the neurofibroma (1) with the overlying skin (2).  
 
File:IPLab5Neurofibromatosis5.jpg|This is a higher-power photomicrograph of the neurofibroma (1) with the overlying skin (2).  

Latest revision as of 19:29, 8 July 2020

Clinical Summary[edit]

A 45-year-old divorced white male came to the emergency room with severe hepatic cirrhosis and aspiration pneumonia. Shortly after admission he developed cardiac arrhythmias and died. Significant past history included alcohol abuse, cirrhosis, and neurofibromatosis. He had no family history of neurofibromatosis, but his condition was diagnosed at age 17 when he developed neurofibromas along the lateral chest wall. There was no history of continued follow-up after this initial diagnosis.

The patient was covered with variably sized subcutaneous nodules ranging from 0.5 to 2.5 cm in diameter. Other significant findings included micronodular hepatic cirrhosis, ascites (500 ml), and splenomegaly.

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Virtual Microscopy[edit]

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Cirrhosis is a liver disease characterized by necrosis, fibrosis, loss of normal liver architecture, and hyperplastic nodules.

In alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents.

Arrhythmias are abnormal heart rhythms.

Ascities is the accumulation of fluid with in the abdominal cavity. There should be less than 30 ml of fluid in the peritoneal cavity.