Difference between revisions of "IPLab:Lab 12:Radiation Changes"
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* [http://peir.path.uab.edu/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images] | * [http://peir.path.uab.edu/library/index.php?/tags/56-radiation PEIR Digital Library: Radiation Images] | ||
* [http://library.med.utah.edu/WebPath/GIHTML/GIIDX.html#5 WebPath: Small Intestine Images] | * [http://library.med.utah.edu/WebPath/GIHTML/GIIDX.html#5 WebPath: Small Intestine Images] | ||
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[[Category: IPLab:Lab 12]] | [[Category: IPLab:Lab 12]] |
Revision as of 15:12, 26 August 2013
Contents
Clinical Summary[edit]
This 46-year-old white female was found to have prolapse of the uterus two years earlier for which a vaginal hysterectomy had been performed. Study of the specimen demonstrated invasive squamous cell carcinoma of the cervix. Subsequently, she underwent a radical parametrectomy, removal of both tubes and ovaries, and partial resection of the bladder. Six months later, a recurrence of the tumor was treated by 6000 rads to the whole pelvis. Subsequently, the patient developed intermittent small bowel obstruction which resulted in the resection of a segment of ileum. She did well following surgery.
Autopsy Findings[edit]
The surgical specimen consisted of a 13-cm segment of ileum having a luminal circumference of 5 cm. There was a full-thickness tear measuring 2.5 cm in the center of the specimen. On opening the bowel, the mucosa was ulcerated and showed a perforation.
Images[edit]
This high-power photomicrograph of the wall of the ileum shows areas of fibrosis (1), inflammatory cells (2), and abnormal pleomorphic cells (3) in the area of radiation injury. The abnormal morphology of these cells is radiation-induced. These cells are often difficult to distinguish from recurrent tumor cells.
Study Questions[edit]
Additional Resources[edit]
Reference[edit]
- eMedicine Medical Library: Intestinal Radiation Injury
- eMedicine Medical Library: Radiation Therapy in Gynecology
- Merck Manual: Radiation Exposure and Contamination
Journal Articles[edit]
- Reis ED, Vine AJ, Heimann T. Radiation damage to the rectum and anus: pathophysiology, clinical features and surgical implications. Colorectal Dis 2002 Jan;4(1):2-12.
Images[edit]
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Parametrectomy is the surgical removal of supporting tissues that surround the uterus.