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File:IPLab13CF14.jpg|Another high-power photomicrograph of intestine shows the vacuolated intestinal epithelial cells lining the crypts and necrotic debris and inspissated secretions within the crypts (arrows).
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== Study Questions ==
* <spoiler text="What is the mode of inheritance of cystic fibrosis (CF)?">CF is autosomal recessive.
The frequency of CF in whites is 1/200. Thus, one out of every 20 whites must be heterozygous (heterozygotes have no recognizable symptoms).
Other racial groups have a very low incidence of CF.</spoiler>
* <spoiler text="What is the sweat chloride test?">CF causes altered cellular chloride transport leading to increased chloride levels in the sweat.
A sweat chloride level greater than 60 mEq/L is diagnostic for CF if other clinical signs are also present.</spoiler>
* <spoiler text="What are the most common presenting signs in patients with CF and when do they occur?">When children are 2-12 months of age they develop malodorous steatorrhea and recurrent chronic pulmonary infections. Lower than normal weight gain is also common.</spoiler>
* <spoiler text="What organs are affected by CF?">Lung - chronic pneumonia, viscous mucous secretions, distended bronchioles, hypertrophy and hyperplasia of mucus-secreting glands, chronic bronchitis and bronchiolitis.
Pancreas - atrophy of exocrine pancreas, plugging of ducts, progressive fibrosis and fatty replacement. Insufficiency of exocrine pancreas leads to steatorrhea and fat soluble vitamin deficiencies (e.g., low vitamin K leads to bleeding disorders).
Liver - plugging of bile canaliculi, biliary cirrhosis.
Salivary glands - dilation of ducts, plugging, squamous metaplasia of lining epithelium, fibrosis.
Wolffian duct obstruction - infertility in males who live to puberty.</spoiler>
{{IPLab 13}}
[[Category: IPLab:Lab 13]]
