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File:IPLab6PAN13.jpg|This is a high-power photomicrograph of the affected vessel in the heart. The vessel lumen is completely occluded.
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== Study Questions ==
* <spoiler text="What vessels are usually affected in PAN?">PAN affects small and medium-sized muscular arteries. The renal and visceral arteries are typically affected while the pulmonary arteries are often spared.</spoiler>
* <spoiler text="What is the etiology of PAN?">The etiology is unknown but the disease is believed to be a type III hypersensitivity reaction Some studies have shown that approximately 30% of patients with PAN have hepatitis B antigenemia. In addition, some patients with PAN have been shown to have circulating antineutrophil cytoplasmic autoantibodies. In some cases the level of these autoantibodies is associated with the severity of the disease.</spoiler>
* <spoiler text="What is the prognosis for patients with PAN?">The clinical course of PAN may be acute, subacute, or chronic and is frequently remittent, with long symptom-free intervals. Acute episodes of the disease are treated with corticosteroids and cyclophosphamide. Aggressive immunosuppressive treatment leads to remission or cure in approximately 90% of patients with PAN.</spoiler>
{{IPLab 6}}
[[Category: IPLab:Lab 6]]
