IPLab:Lab 1:Fat Necrosis

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Clinical Summary[edit]

This was a 37-year-old female with chronic renal failure who underwent a cadaveric renal transplant. Following transplantation she developed oral candidiasis, pneumonia, pyuria, and gastrointestinal bleeding. Subsequently, the patient became septic and died.

Major findings at autopsy included extensive hemorrhagic bronchopneumonia and multiple ulcers affecting the stomach and esophagus. There was also evidence of disseminated intravascular coagulation (DIC) with multiple hemorrhages present. Firm, whitish foci of necrotic tissue were found in the fat around the pancreas.


Virtual Microscopy[edit]

Pancreatic Fat Necrosis[edit]

Normal Pancreas[edit]

Study Questions[edit]

Additional Resources[edit]


Journal Articles[edit]


Renal failure is the severe reduction of renal function and often leads to reduced urinary output.

Candidiasis is an infection by the fungus Candida in the oral cavity.

In alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents.

Pyuria is the presence of white blood cells (pus) in the urine.

Sepsis is the presence and persistence of pathogenic microorganisms and their toxins in the blood.

DIC is the development of small thrombi within the microcirculation throughout the body.