IPLab:Lab 11:Chagas Disease
Contents
Clinical Summary[edit]
This 12-year-old boy, whose family had recently emigrated from Brazil, presented to the emergency room with a three-day history of malaise, fever, anorexia, and edema of the face and upper extremities. On physical examination the patient had generalized lymphadenopathy and hepatosplenomegaly. The patient was tachycardic and dysgenic with signs of congestive heart failure. A cardiac biopsy was performed which revealed an active myocarditis with leishmanial forms of parasitic organisms within cardiac myocytes. Close examination of peripheral blood smears revealed occasional circulating trypomastigotes. A complement fixation test for antibodies to Trypanosoma cruzi was strongly positive.
Images[edit]
Virtual Microscopy[edit]
Study Questions[edit]
Additional Resources[edit]
Reference[edit]
- eMedicine Medical Library: Chagas Disease (American Trypanosomiasis)
- eMedicine Medical Library: Trypanosomiasis
- Merck Manual: Chagas Disease
- Merck Manual: African Trypanosomiasis
Journal Articles[edit]
- Bestetti RB. Predictors of unfavourable prognosis in chronic Chagas' disease. Trop Med Int Health 2001 Jun;6(6):476-83.
- Calzada JE, Nieto A, Beraún Y, Martín J. Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy. Tissue Antigens 2001 Sep;58(3):154-8.
- Bern C. Chagas’ Disease. NEJM 2015 July 30;373:456-466.
Images[edit]
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Arrhythmias are abnormal heart rhythms.