Difference between revisions of "IPLab:Lab 11:Chagas Disease"

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File:IPLab11Chagas6.jpg|This is a higher-power photomicrograph of an H & E stained heart biopsy from this patient. Note the T. cruzi amastigotes (arrows) within this longitudinal section of a myocyte.  
 
File:IPLab11Chagas6.jpg|This is a higher-power photomicrograph of an H & E stained heart biopsy from this patient. Note the T. cruzi amastigotes (arrows) within this longitudinal section of a myocyte.  
 
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== Virtual Microscopy ==
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<peir-vm>IPLab11Chagas</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==
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== Additional Resources ==
 
== Additional Resources ==
 
=== Reference ===
 
=== Reference ===
 
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* [http://emedicine.medscape.com/article/214581-overview eMedicine Medical Library: Chagas Disease (American Trypanosomiasis)]
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* [http://emedicine.medscape.com/article/1000389-overview eMedicine Medical Library: Trypanosomiasis]
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* [http://www.merckmanuals.com/professional/infectious_diseases/extraintestinal_protozoa/chagas_disease.html Merck Manual: Chagas Disease]
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* [http://www.merckmanuals.com/professional/infectious_diseases/extraintestinal_protozoa/african_trypanosomiasis.html Merck Manual: African Trypanosomiasis]
  
 
=== Journal Articles ===
 
=== Journal Articles ===
 
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* Bestetti RB.  [http://www.ncbi.nlm.nih.gov/pubmed/11422962 Predictors of unfavourable prognosis in chronic Chagas' disease].  ''Trop Med Int Health'' 2001 Jun;6(6):476-83.
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* Calzada JE, Nieto A, Beraún Y, Martín J.  [http://www.ncbi.nlm.nih.gov/pubmed/11703822 Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy].  ''Tissue Antigens'' 2001 Sep;58(3):154-8.
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* Bern C.  [http://www.nejm.org/doi/full/10.1056/NEJMra1410150 Chagas’ Disease].  ''NEJM'' 2015 July 30;373:456-466.
  
 
=== Images ===
 
=== Images ===
 
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* [{{SERVER}}/library/index.php?/tags/2166-chagas_disease PEIR Digital Library: Chagas Disease]
 
 
== Related IPLab Cases ==
 
 
 
  
 
{{IPLab 11}}
 
{{IPLab 11}}
  
 
[[Category: IPLab:Lab 11]]
 
[[Category: IPLab:Lab 11]]

Latest revision as of 14:31, 25 August 2016

Clinical Summary[edit]

This 12-year-old boy, whose family had recently emigrated from Brazil, presented to the emergency room with a three-day history of malaise, fever, anorexia, and edema of the face and upper extremities. On physical examination the patient had generalized lymphadenopathy and hepatosplenomegaly. The patient was tachycardic and dysgenic with signs of congestive heart failure. A cardiac biopsy was performed which revealed an active myocarditis with leishmanial forms of parasitic organisms within cardiac myocytes. Close examination of peripheral blood smears revealed occasional circulating trypomastigotes. A complement fixation test for antibodies to Trypanosoma cruzi was strongly positive.

Images[edit]

Virtual Microscopy[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

Arrhythmias are abnormal heart rhythms.