IPLab:Lab 3:Healed Myocardial Infarction

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Clinical Summary

This 37-year-old white female with a 22 year history of insulin-dependent diabetes was admitted to the hospital 10 hours prior to death complaining of chest pain and shortness of breathShortness of breath is a common clinical manifestation of heart failure.. Three months before, she had begun to experience progressive weakness and for the previous 3 weeks she noticed increasing dyspnea on exertion and worsening of a chronic cough.

Autopsy Findings

Autopsy showed a 340-gram heartA normal heart weighs 300 grams (range: 270 to 360 grams). with extensive transmural reddish discoloration of the anterolateral portion of the myocardium of the left ventricle. There was severe atherosclerotic narrowingAtherosclerosis is the deposition of lipid into the intima of arteries, resulting in narrowing of the vessel lumen. of all coronary arteries especially the left anterior descending. The lungs showed pulmonary edemaPulmonary edema refers to the accumulation of fluid in the pulmonary alveolar and tissue spaces as a result of changes in capillary permeability and/or increases in capillary hydrostatic pressure. and early bronchopneumonia.


Virtual Microscopy

Early (Inflammatory Response)

Late (Replacement Fibrosis)

Study Questions

Additional Resources


Journal Articles


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