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File:IPLab3Sarcoidosis6.jpg|This is a higher-power photomicrograph of an asteroid body (arrow) inside of a multinucleated giant cell.
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Study Questions
* <spoiler text="What is sarcoidosis?">The exact cause of sarcoidosis is unknown. Sarcoidosis is characterized by non-caseating granulomas in many tissues and organs.</spoiler>
* <spoiler text="What is the characteristic phenotype of sarcoid granulomas?">The typical characteristic of a sarcoid granuloma is a non-caseating granuloma which consists of an aggregate of tightly-clustered epitheliod cells, often with Langhans’ or multinucleated giant cells. Occasionally, asteroid bodies may be seen.</spoiler>
* <spoiler text="What are asteroid bodies and are they pathognomonic for sarcoid or are they seen in other diseases?">Asteroid bodies are stellate inclusions within giant cells. They are not pathognomonic for sarcoid; they can be seen in other granulomatous disease processes (e.g., berylliosis).</spoiler>
{{IPLab 3}}
