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Cytologically Yours: CoW: 20140220

75 bytes added, 22:46, 4 March 2014
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===Cytology===
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CytologicallyYoursCoW20140220Cytology1.jpg|40x 20x magnification of highly atypical malignant appearing cellsa cellular specimen with numerous follicles and absent colloid.CytologicallyYoursCoW20140220Cytology2.jpg|20x 40x magnification showing osteoid formationwith follicular cells forming microfollicular groups and inspissated colloid.CytologicallyYoursCoW20140220Cytology3.jpg|40x 60x magnification showing osteoid formation with follicular cells forming microfollicular groups and malignant appearing cellsinspissated colloid.CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification showing osteoid formation with follicular cells forming microfollicular groups and malignant appearing cellsinspissated colloid.CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of osteoidPap stained material showing magnification with follicular cells forming microfollicular groups and inspissated colloid..CytologicallyYoursCoW20140220Cytology6.jpg|60x magnification of Pap stained material with microfollicles.
</gallery>
====Resident Questions====
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma. </spoiler>
* <spoiler text="What are the molecular features that differentiate follicular carcinoma and papillary carcinoma?>"> Follicular carcinoma show PAX8-PPAR gamma translocations and papillary carcinoma shows BRAF mutations and RET/PTC rearrangements. </spoiler>
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