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Created page with "==Clinical History== 45 year old female with hypothyroidism. ==Cytology== <gallery heights="250px" widths="250px"> CytologicallyYoursUnknowns201311-1-01.jpg CytologicallyYour..."
==Clinical History==
45 year old female with hypothyroidism.
==Cytology==
<gallery heights="250px" widths="250px">
CytologicallyYoursUnknowns201311-1-01.jpg
CytologicallyYoursUnknowns201311-1-02.jpg
</gallery>
===Resident Questions===
* <spoiler text="Diagnosis?">Lymphocytic thyroiditis (Hashimoto thyroiditis). </spoiler>
* <spoiler text="What are the clinical findings that support this diagnosis?">
* The diagnosis of Hashimoto is based on one or more circulating autoantibodies. The most common are anti-thyroglobulin and anti-thyroid peroxidase (TPO).
</spoiler>
==Additional Teaching Points==
===Immunohistochemistry===
* TTF-1 (nuclear stain)
** Thyroid Transcription factor1 regulates transcription of genes specific to the thyroid, lung, and diencephalon
** If metastatic thyroid cancer to the lung is ruled out by morphology or +thyroglobulin; then a +TTF1 supports adenocarcinoma originating from the lung
* P63 (nuclear stain) and 34BE12 (cytoplasmic stain)
** Used for squamous differentiation
* TTF1 is more sensitive than p63
** If a tumor stains for both it is more likely to be adenocarcinoma
* Napsin A(cytoplasmic stain)
** Granular staining pattern
** Marker for adenocarcinoma
{{Cytologically Yours}}
[[Category:Unknowns]]
[[Category:Respiratory]]
45 year old female with hypothyroidism.
==Cytology==
<gallery heights="250px" widths="250px">
CytologicallyYoursUnknowns201311-1-01.jpg
CytologicallyYoursUnknowns201311-1-02.jpg
</gallery>
===Resident Questions===
* <spoiler text="Diagnosis?">Lymphocytic thyroiditis (Hashimoto thyroiditis). </spoiler>
* <spoiler text="What are the clinical findings that support this diagnosis?">
* The diagnosis of Hashimoto is based on one or more circulating autoantibodies. The most common are anti-thyroglobulin and anti-thyroid peroxidase (TPO).
</spoiler>
==Additional Teaching Points==
===Immunohistochemistry===
* TTF-1 (nuclear stain)
** Thyroid Transcription factor1 regulates transcription of genes specific to the thyroid, lung, and diencephalon
** If metastatic thyroid cancer to the lung is ruled out by morphology or +thyroglobulin; then a +TTF1 supports adenocarcinoma originating from the lung
* P63 (nuclear stain) and 34BE12 (cytoplasmic stain)
** Used for squamous differentiation
* TTF1 is more sensitive than p63
** If a tumor stains for both it is more likely to be adenocarcinoma
* Napsin A(cytoplasmic stain)
** Granular staining pattern
** Marker for adenocarcinoma
{{Cytologically Yours}}
[[Category:Unknowns]]
[[Category:Respiratory]]
