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IPLab:Lab 7:Bronchogenic Carcinoma

352 bytes removed, 9 July
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This 55-year-old white male had a long history of emphysema and a 60-70 pack-year smoking history. He was in his usual state of health until about one month before admission, at which time he developed increasing dyspnea on exertion. At the same time, his sputum increased from two tablespoons to half a cup of yellow blood-streaked sputum a day. Chest x-ray showed a right hilar mass. Sputum cytology revealed abnormal cells that were "positive for malignancy." He later developed pneumonia and fever. The patient expired soon thereafter.
== Autopsy Findings ==Significant At autopsy significant findings included advanced carcinoma of the right main stem bronchus with extension across the carina to produce obstruction of the left main stem bronchus. There was left lower lobe pneumonia and left upper lobe atelectasis. Extensive metastases were present in regional lymph nodes as well as the pericardium, left atrium, and right kidney.
== Images ==
File:IPLab7Bronchogenic3.jpg|This is a photomicrograph of bronchus with ulcerated mucosal surface on the right (1). The submucosa is completely filled with tumor down to the cartilage (2).
File:IPLab7Bronchogenic4.jpg|This is a higher-power photomicrograph of bronchus with the ulcerated mucosal surface on the right and tumor underneath.
File:IPLab7Bronchogenic5IPLab7Bronchogenic5x.jpg|This is a higher-power photomicrograph of the mucosal surface (right) with an area of hemorrhage (arrow) and underlying tumor (left). File:IPLab7Bronchogenic6.jpg|This is a photomicrograph of tumor from an area of invasion with compression of fibrous stroma and focal necrosis. File:IPLab7Bronchogenic7.jpg|This is a high-power photomicrograph showing cytologic detail of the tumor cells with an area foci of necrosis (1) and a more differentiated area with keratin pearl formation (2arrows). File:IPLab7Bronchogenic8IPLab7Bronchogenic6b.jpg|This is a high power photomicrograph of tumor cells with an area of central necrosis (arrow)more keratin production. File:IPLab7Bronchogenic9IPLab7Bronchogenic8b.jpg|This high-power photomicrograph of tumor shows the cytologic detail keratin production and areas of a less-differentiated area of neoplasm with cellular anaplasianecrosis (N).
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== Virtual Microscopy ==
<peir-vm>IPLab7Bronchogenic</peir-vm>
== Study Questions ==
=== Images ===
* [http://peir.path.uab.edu{{SERVER}}/library/index.php?/tags/27-lung/112-carcinoma PEIR Digital Library: Lung Carcinoma Images]
* [http://library.med.utah.edu/WebPath/LUNGHTML/LUNGIDX.html WebPath: Pulmonary Pathology]

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