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File:IPLab13Myelomeningocele7.jpg|This high-power photomicrograph of the spinal cord within the vertebral column shows the hemorrhage (arrows) in this region.
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== Study Questions ==
* <spoiler text="What are the various types of neural tube defects?">Neural tube defects (NTD) are abnormalities of both neural tissue and overlying bone and/or soft tissues which result in failure to close of a portion of the neural tube or reopening of a region that had previously been closed. The most common forms of NTD in newborns involve the caudal portions of the spinal cord.
NTDs may include:
* Anencephaly - malformation of the anterior neural tube leading to failure of the brain and calvarium to develop
* Encephalocele - diverticulum of malformed brain tissue extending through a hole in the cranium.
* Spinal dysraphism or spina bifida - asymptomatic bony defect (spina bifida occulta) or a severe malformation with a flattened, disorganized segment of spinal cord, associated with an overlying meningeal out-pouching.
* Meningocele - defect in the spinal column with meningeal tissue extending through it.
* Myelomeningocele - defect in the spinal column with meningeal and spinal cord tissue extending through it.</spoiler>
* <spoiler text="What is the etiology of neural tube defects?">The etiology of NTDs is generally unknown, though most NTDs appear to be due to multifactorial inheritance and environmental factors.
The frequency of NTDs varies widely among ethnic groups and there is a recurrence rate for NTDs in subsequent pregnancies of approximately 4 to 5%.
Recent evidence has shown that folate deficiency during the first few weeks of gestation increases the risk of NTDs. Other risk factors include diabetes mellitus, hyperthermia, alcohol ingestion and exposure to other toxic substances.</spoiler>
* <spoiler text="What kinds of clinical problems can be seen in patients with myelomeningoceles?">Clinical problems can result from damage to the spinal cord due to the myelomeningocele or due to secondary infection.
Clinical deficits usually occur in motor and sensory function in the lower extremities as well as disturbances of bowel and bladder control.</spoiler>
{{IPLab 13}}
[[Category: IPLab:Lab 13]]
