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File:IPLab6GravesDisease7.jpg|Closer view of cut surface of the thyroid with nodular goiter. Note the multilobular appearance of the tissue.
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== Study Questions ==
* <spoiler text="What is the immunologic mechanism responsible for Graves' disease?">Autoantibodies directed towards the TSH receptor of the thyroid cause stimulation of the thyroid leading to increased secretion of thyroid hormones and growth of the thyroid gland.</spoiler>
* <spoiler text="What role does genetics play in the predisposition to Graves' disease?">* Graves' disease is more common in females than males
* It has been linked to HLA-B8 and DR3 in whites but different haplotypes in Asians
* It has a familial predisposition
* It is more common in patients with other forms of autoimmune thyroid problems (e.g., Hashimoto's thyroiditis)</spoiler>
* <spoiler text="Does Graves' disease predispose to thyroid cancer?">There is little evidence to suggest an increased frequency of thyroid cancer in patients with Graves' disease.</spoiler>
{{IPLab 6}}
[[Category: IPLab:Lab 6]]
