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File:IPLab4Thrombosis10.jpg|This is a high-power photomicrograph of the luminal surface of a re-canalized vessel. Note that the vessel lumen is lined by endothelial cells (arrows).
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== Study Questions ==
* <spoiler text="What is the most common cause of acute myocardial infarction?">Thrombotic occlusion of a coronary artery at the site of an atherosclerotic plaque. Usually, there is rupture of the fibrous cap with exposure of collagen and release of atheromatous material which initiates thrombosis.</spoiler>
* <spoiler text="What is the source for the fibroblasts and endothelial cells that are present in organizing thrombi?">Organization of a thrombus involves a process similar to the normal healing response. First there is inflammation with macrophages that phagocytose the thrombotic material. Then fibroblasts and endothelial cells from the vessel wall and the vasa vasorum of the vessel migrate into thrombotic material. This process results in a picture similar to granulation tissue in a healing wound.</spoiler>
* <spoiler text="Does recanalization of a thrombus results in normal blood flow to the tissue?">Usually not. The recanalized lumen is not very large and by the time the thrombus is recanalized, the tissue supplied by that artery is usually already dead. Any blood flow down this vessel will help to accelerate the wound healing process in the tissue downstream.</spoiler>
{{IPLab 4}}
[[Category: IPLab:Lab 4]]
