Cytologically Yours: Unknowns: 201312: Case 3
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Clinical History
54 year old female. Left breast 1cm nodule. FNA.
Cytology
Resident Questions
- <spoiler text="Diagnosis?">
- Cytology diagnosis: Proliferative lesion, consistent with fibroadenoma.
- Surgical diagnosis: Fibroadenoma </spoiler>
Surgical Pathology
Cytologic Features
- Biphasic appearance: Epithelium and mesenchymal/stromal
- Epithelium appears as cohesive monolayer sheets of well-organized epithelium with branching and papillary-like architecture (staghorn) or tubular
- Naked bipolar myoepithelial cells in the background (rice grain appearance)
- Variably cellular stromal fragments