Difference between revisions of "IPLab:Lab 8:Poliomyelitis"

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(Created page with "== Images == <gallery heights="250px" widths="250px"> File:IPLab8Polio1.jpg|This is a low-power photomicrograph of a section of spinal cord from this case. Note that the anter...")
 
(Virtual Microscopy)
 
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== Clinical Summary ==
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Six days before his death, this 31-year-old white male became acutely ill with fever followed by an ascending paralysis which began in his feet. Three days later he was hospitalized because of difficulty in breathing. A lumbar puncture was performed and the patient's spinal fluid contained increased protein and polymorphonuclear leukocytes (4.30 PMNs/mm³). He died on the third hospital day.
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== Autopsy Findings ==
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At autopsy, the thoracic and lumbar portions of the spinal cord were softer than normal and focally hemorrhagic.
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== Images ==
 
== Images ==
 
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File:IPLab8Polio5.jpg|This is another high-power photomicrograph of the anterior horn with inflammatory cell infiltrate and total loss of neurons.  
 
File:IPLab8Polio5.jpg|This is another high-power photomicrograph of the anterior horn with inflammatory cell infiltrate and total loss of neurons.  
 
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== Virtual Microscopy ==
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=== Poliomyelitis ===
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<peir-vm>IPLab8Polio</peir-vm>
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=== Normal Spinal Cord ===
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<peir-vm>IPLab8Polio-Normal_cord</peir-vm>
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== Study Questions ==
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* <spoiler text="How does poliovirus cause cell death?">Poliovirus replicates inside neurons and causes lysis of the cell.</spoiler>
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* <spoiler text="What is the mode of transmission of poliovirus?">Poliovirus is an enterovirus that is usually acquired from contaminated water. It has been effectively controlled by immunization; however, among the nonimmune it causes a nonspecific gastroenteritis. In a small fraction of the vulnerable population, it can invade the nervous system where it attacks lower motor neurons.</spoiler>
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== Additional Resources ==
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=== Reference ===
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* [http://emedicine.medscape.com/article/967950-overview eMedicine Medical Library: Pediatric Poliomyelitis]
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* [http://www.merckmanuals.com/professional/infectious_diseases/enteroviruses/poliomyelitis.html Merck Manual: Poliomyelitis]
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* [http://www.polioeradication.org/ The WHO: Global Polio Eradication Initiative]
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=== Journal Articles ===
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* Alexander L, Birkhead G, Guerra F, Helms C, Hinman A, Katz S, LeBaron CW, Modlin J, Murphy TV; National Vaccine Advisory Committee-Advisory Committee on Immunization Practices Joint Working Group; Centers for Disease Control and Prevention.  [http://www.ncbi.nlm.nih.gov/pubmed/15583093 Ensuring preparedness for potential poliomyelitis outbreaks: recommendations for the US poliovirus vaccine stockpile from the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP)].  ''Arch Pediatr Adolesc Med'' 2004 Dec;158(12):1106-12.
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=== Images ===
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* [{{SERVER}}/library/index.php?/tags/2149-polio PEIR Digital Library: Polio Images]
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* [http://library.med.utah.edu/WebPath/CNSHTML/CNSIDX.html#7 WebPath: CNS Pathology: Acquired and Congenital Degenerative Diseases]
  
 
{{IPLab 8}}
 
{{IPLab 8}}
  
 
[[Category: IPLab:Lab 8]]
 
[[Category: IPLab:Lab 8]]

Latest revision as of 16:30, 3 January 2014

Clinical Summary[edit]

Six days before his death, this 31-year-old white male became acutely ill with fever followed by an ascending paralysis which began in his feet. Three days later he was hospitalized because of difficulty in breathing. A lumbar puncture was performed and the patient's spinal fluid contained increased protein and polymorphonuclear leukocytes (4.30 PMNs/mm³). He died on the third hospital day.

Autopsy Findings[edit]

At autopsy, the thoracic and lumbar portions of the spinal cord were softer than normal and focally hemorrhagic.

Images[edit]

Virtual Microscopy[edit]

Poliomyelitis[edit]

Normal Spinal Cord[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

Normally, there should be no PMNs in a patient's spinal fluid.

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.