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IPLab:Lab 7:Adenocarcinoma

216 bytes added, 01:16, 9 July 2020
Autopsy Findings
== Clinical Summary ==
Approximately four months prior to admission, this 68-year-old male began having "sharp, shooting pains" in the lower abdomen. A barium enema at that time was reported as normal. Two months later, the barium study was repeated because of persistent diarrhea and On admission a CT scan showed a filling defect mass in the transverse colon. The patient refused to undergo an exploratory a laparotomyand declined further treatment. During the week prior to this admission, the patient had recurrent diarrhea, cramping Six months later he returned with severe abdominal pain, and marked rectal bleeding. He was hospitalized and required 2500 ml of blood to return his hematocrit to normal. A a colectomy was done from the hepatic flexure to the rectosigmoidperformed.
== Autopsy Findings == The segment of colon contained numerous polyps and an annular tumor which was 6.7 cm in diameter. Proctoscopic Endoscopic examination of the ascending colon revealed two more polyps which were removed.
== Images ==
File:IPLab7ColonCA9.jpg|This is a segment of distal colon from another case. Note the annular tumor that severely compromises the lumen of the colon. There is dilation of the colon proximal to the tumor.
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== Virtual Microscopy ==
<peir-vm>IPLab7ColonCA</peir-vm>
== Study Questions ==
=== Journal Articles ===
* Yuen ST, Wong MP, Chung LP, Chan SY, Cheung N, Ho J, Leung SY. [http://www.ncbi.nlm.nih.gov/pubmed/9543668 Up-regulation of lysozyme production in colonic adenomas and adenocarcinomas]. ''Histopathology'' 1998 Feb;32(2):126-32.
* Strum WB. [http://www.nejm.org/doi/full/10.1056/NEJMra1513581 Colorectal Adenomas]. ''NEJM'' 2016 March 17 374:1065-1075.
=== Images ===
* [http://peir.path.uab.edu{{SERVER}}/library/index.php?/tags/66-colon/112-carcinoma PEIR Digital Library: Colon Carcinoma Images]
* [http://library.med.utah.edu/WebPath/GIHTML/GIIDX.html#10 WebPath: Colon and Appendix]
== Related IPLab Cases ==
* [[IPLab:Lab 7:Metastatic Adenocarcinoma|Lab 7: Lung & Liver: Metastatic Adenocarcinoma]]* [[IPLab:Lab 7:Lip SCC|Lab 7: Lip: Squamous Cell Carcinoma]]* [[IPLab:Lab 7:Esophagus SCC|Lab 7: Esophagus: Squamous Cell Carcinoma]]* [[IPLab:Lab 7:IDC|Lab 7: Breast: Infiltrating Ductal Carcinoma]]* [[IPLab:Lab 7:Bronchogenic Carcinoma|Lab 7: Lung: Bronchogenic Carcinoma]]
{{IPLab 7}}
[[Category: IPLab:Lab 7]]

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