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IPLab:Lab 1:Fat Necrosis

823 bytes removed, 18:34, 1 August 2019
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Major findings at autopsy included extensive hemorrhagic bronchopneumonia and multiple ulcers affecting the stomach and esophagus. There was also evidence of disseminated intravascular coagulation (DIC) with multiple hemorrhages present. Firm, whitish foci of necrotic tissue were found in the fat around the pancreas.
 
== Autopsy Findings ==
Major findings at autopsy included extensive hemorrhagic bronchopneumonia (Pseudomonas aeruginosa) and multiple ulcers affecting the stomach and esophagus. There was also evidence of disseminated intravascular coagulation (DIC) with multiple hemorrhages present. Firm, whitish foci of necrotic tissue were found in the fat around the pancreas.
== Images ==
File:IPLab1FatNecrosis1.jpg|This gross photograph shows the intestines and omentum at autopsy. Note the small (5-15 mm in diameter) white nodules on the surface of the omental and mesenteric fat tissue (arrows).
File:IPLab1FatNecrosis2.jpg|This gross photograph of the pancreas from this case shows white nodules (arrows) in the pancreas and the adjacent mesenteric fat tissue.
File:IPLab1FatNecrosis3.jpg|This low-power photomicrograph of the pancreas from this case shows the fat tissue (1) surrounding the pancreas. Note the rim of inflammatory cells (arrows) and the blue areas in the that represent calcified fat adjacent to the pancreas (2).File:IPLab1FatNecrosis4IPLab1FatNecrosis5.jpg|This highmedium-power photomicrograph shows areas of inflammation (1) and fat necrosis (arrows) in the peripancreatic fat tissue (2) of the pancreas from this case.File:IPLab1FatNecrosis5.jpg|Another high-power photomicrograph shows blue discoloration in of the fat tissue in the interlobular spaces (1) of the pancreas. This blue to purple staining represents calcium deposits that occur after enzymatic necrosis of the fat cells releases free fatty acids.
File:IPLab1FatNecrosis6.jpg|A higher-power photomicrograph of the previous slide contains a small area of fat necrosis (1) in the upper right portion of the image. The fat necrosis is within the fat tissue that is normally found adjacent to the pancreas. The appearance of the pancreatic tissue in this area is somewhat disrupted due to autolysis (the pancreas autolyzes very rapidly after death) but there is some premortem necrosis as well.
File:IPLab1FatNecrosis7.jpg|This is a higher-power photomicrograph of the fat necrosis involving the fat cells in the interlobular spaces (arrow) of the pancreas. Note the blue to purple staining of the calcium deposits within the fat cells.File:IPLab1FatNecrosis8IPLab1FatNecrosis10.jpg|This high-power photomicrograph demonstrates fat necrosis in the interlobular spaces of the pancreas. Note the granular blue-staining calcium deposits (arrows) within the fat cells. The clear areas represent artifact caused by the "washing-out" of fat from cells during tissue processing for histology.File:IPLab1FatNecrosis9.jpg|This is another high-power photomicrograph demonstrating the calcification (arrows) seen in fat necrosis involving the interlobular spaces of the pancreas.
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