Cytologically Yours: Unknowns: 201311: Case 3

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Clinical History

32 year old male with a solid thyroid nodule on ultrasound.

Cytology

Resident Questions

  • What are the most common molecular associations?
  • What other entities of the thyroid may exhibit intranuclear pseudoinclusions?
  • Cytologic Features

    • Powdery chromatin, grooves, pseudoinclusions, nucleolus
    • Crowding and overlapping
    • Sheets, papillae
    • Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated)
    • Psammoma bodies
    • Giant cells
    • Bubble gum colloid
    • Septated cytoplasm