Cytologically Yours: Unknowns: 201311: Case 3
32 year old male with a solid thyroid nodule on ultrasound.
- Papillary carcinoma.
- Rearrangements of Ret proto-oncogene on Chromosome 10 (RET/PTC).
- Point mutations of BRAF and RAS
- Medullary carcinoma.
- Powdery chromatin, grooves, pseudoinclusions, nucleolus
- Crowding and overlapping
- Sheets, papillae
- Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated)
- Psammoma bodies
- Giant cells
- Bubble gum colloid
- Septated cytoplasm