IPLab:Lab 6:Hashimoto's Thyroiditis
This was a 49-year-old woman who complained during her yearly physical examination of tiredness and difficulty concentrating. She attributed these symptoms to stress at work. She had gained weight over the last year and despite warm weather, she felt chilled without a sweater. Family history was significant for hypothyroidism in her mother and older sister. On physical examination she had a pulse of 58 bpmA normal pulse rate is 60 to 100 bpm. and a blood pressure of 138/88A normal blood pressure reading would be 120/80 mm Hg. mm Hg. Examination of her neck disclosed a small thyroid gland with a palpable pyramidal lobe and a firm, bosselatedBosselated means covered with rounded protuberances. texture. Serum taken at this time demonstrated a total T4 of 7.0 mcg/dLA normal T4 level is 4 to 11 mcg/dL. and a TSH of 22.0 mcIU/mlA normal TSH level is 0.32 to 5.00 mcIU/dL.. In addition, antithyroglobulin antibodiesAntithyroglobulin antibodies are autoimmune antibodies directed against thyroglobulin. Over half of all patients with Hashimotos thyroiditis have positive titers, although they are also found in other types of thyroiditis. were positive at 1 to 640A normal antithyroglobulin antibody titer would be less than 1 to 10. and antimicrosomal antibodiesAntimicrosomal antibodies are autoimmune antibodies directed at the thyroid gland. They are seen in almost all patients with Hashimotos thyroiditis. were positive at 1 to 5120A normal antimicrosomal antibody titer would be less than 1 to 100.. These results supported the clinical impression of hypothyroidism; also, the texture of her thyroid gland and a positive family history suggested an autoimmuneAutoimmune disorders involve an immune response directed at the host's own cells. etiological factor. She was referred to an endocrinologist for further evaluation; however, before beginning treatment she died suddenly from a ruptured berry aneurysmA berry aneurysm is a small saccular arterial aneurysm usually found at a vessel junction in the circle of Willis. These aneurysms frequently rupture, causing a subarachnoid hemorrhage. of the middle cerebral artery.
At autopsy, significant subarachnoid hemorrhage from the ruptured berry aneurysmA berry aneurysm is a small saccular arterial aneurysm usually found at a vessel junction in the circle of Willis. These aneurysms frequently rupture, causing a subarachnoid hemorrhage. was documented. In addition, the thyroid gland was mildly enlarged and firm. On cut section the tissue was slightly pale.
- What signs and symptoms in this patient suggest a diagnosis of hypothyroidism and what are some of the other signs and symptoms seen with hypothyroidism?
Fatigue, lethargy, slowed speech, cold intolerance, dry skin, course hair, puffy face, myxedema, slowed reflexes, and diffuse goiter.
- What is the pathogenesis of Hashimoto’s thyroiditis and how does this disease differ from Grave’s disease or nutritional goiter?
Hashimoto's thyroiditis is characterized by Iymphocytic infiltration of the thyroid gland and production of antibodies that recognize thyroid-specific antigens. It is currently thought that the disease is caused by abnormal suppressor T-lymphocyte function which results in a localized cell-mediated immune response directed toward the thyroid parenchymal cells. The pathogenesis is not completely understood. In contrast Graves' disease is caused by production of antibodies that mimic the action of thyroid-stimulating hormone. Nutritional goiter is caused by iodine deficiency.
The gland is usually diffusely enlarged, firm, and slightly lobular. The capsule is intact, and the cut surface is light tan and has a slight lobular pattern. Microscopically there is massive infiltration of the thyroid gland by lymphocytes and plasma cells. Germinal centers can often be seen in the gland. Thyroid follicles are usually absent and the few remaining follicles are devoid of colloid.
- eMedicine Medical Library: Hashimoto Thyroiditis
- eMedicine Medical Library: Hypothyroidism
- Merck Manual: Overview of Thyroid Function
- Merck Manual: Hashimoto's Thyroiditis
- Merck Manual: Hypothyroidism
- Agrawal P, Ogilvy-Stuart A, Lees C. Intrauterine diagnosis and management of congenital goitrous hypothyroidism. Ultrasound Obstet Gynecol 2002 May;19(5):501-5.