IPLab:Lab 6:Rheumatoid Arthritis
This 57-year-old white female had suffered from rheumatoid arthritis for 20 years. During this period, many joints were involved, some seriously. Because of the severe pain of this arthritis the patient was placed on steroids and was given analgesics, some of which contained acetaminophen. The patient also took additional analgesics (aspirin and/or acetaminophen) to help control the pain. The patient was admitted to the emergency room for weakness and hematemesisHematemesis is the vomiting of blood.. On admission the patient's hematocrit was 21%A hematocrit value represents the number of packed red cells in mL per 100 mL of centrifuged whole blood--expressed as a percentage. A normal hematocrit for a female is 34 to 44%.. Endoscopy demonstrated a large bleeding ulcer and fresh blood in the stomach and proximal duodenum. The sites of bleeding were cauterized; however, shortly after the procedure the patient became hypotensive and died despite aggressive resuscitation.
There were numerous erosions and ulcers in the gastrointestinal tract and a large quantity of fresh blood in the gastrointestinal tract. There was also significant swelling and deformation in multiple joints. On the medial aspect of the right foot there was a firm, irregular, rubbery subcutaneous nodule measuring 2 x 1.5 cm. The cut surface was whitish-yellow and fibrous.
Inflamed and hyperemic synovium.
Rheumatoid nodules occur in 25% of patients with rheumatoid arthritis (RA). Rheumatoid nodules occur on pressure points (elbows, occiput, lumbosacral area, foot) and are composed of a central area of fibrinoid necrosis surrounded by a rim of epithelioid macrophages, lymphocytes, and plasma cells. The morphology of the rheumatoid nodule is similar to the tissue reaction seen in the joints.
- The exact pathogenesis of rheumatoid arthritis (RA) is not known. What are some of the factors that are associated with RA?
Genetic susceptibility, exposure to a primary exogenous arthritogen, an autoimmuneAutoimmune disorders involve an immune response directed at the host's own cells. reaction within the synovial membranes, and release of cytokines that mediate joint damage.
IgM antibodies (perhaps originating from the joints) that are directed against the Fc portion of autologous IgG.
- eMedicine Medical Library: Rheumatoid Arthritis
- Merck Manual: Rheumatoid Arthritis (RA)
- National Library of Medicine: Rheumatoid Arthritis
- Carter RA, O'Donnell K, Sachthep S, Cicuttini F, Boyd AW, Wicks IP. Characterization of a human synovial cell antigen: VCAM-1 and inflammatory arthritis. Immunol Cell Biol 2001 Oct;79(5):419-28.