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IPLab:Lab 7:IDC

146 bytes added, 02:03, 9 July 2020
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This 66-year-old female had had a mass of increasing size in the left breast for many years. A modified radical mastectomy was performed. At that time, invading carcinoma was left around the subclavian artery and 9 of 9 axillary lymph nodes were found to contain metastases. Later, pleural effusions recurred despite radiation therapy. The patient died 3 months after surgery.
== Autopsy Findings == The At autopsy the left breast was large (1700 grams), measuring 34 x 22 x 7 cm. A very large tumor involving all quadrants and measuring about 14 cm in diameter was noted. The nipple and skin were involved, the latter showing the typical orange peel appearance. On section, virtually the entire breast was replaced by a tumor composed of firm, yellowish-white tissue. Extension into the fatty tissue and to the skin was evident grossly.
== Images ==
<gallery heights="250px" widths="250px">
File:IPLab7IDC1IPLab7IDC1b.jpg|This is a gross photograph of the surgical specimen of breast with infiltrating duct carcinoma. Note the tumor tissue under the area of the nipple. The tumor infiltrates in an irregular fashion into the breast parenchyma. Note the nipple retraction caused by this neoplasm.
File:IPLab7IDC2.jpg|These are sections of normal breast (lower) and breast tissue with infiltrating duct carcinoma (upper). Note the increased cellularity (increased blue staining due to the increased number of nuclei) in the tumor tissue.
File:IPLab7IDC3.jpg|This is a section of breast with small groups of carcinoma cells throughout the breast tissue and invading through the dermis.
File:IPLab7IDC8.jpg|This is a high-power photomicrograph demonstrating the growth pattern of the tumor. The tumor consists of malignant duct-lining cells growing in cords, solid cell nests, tubules, and glands. The cytologic detail of tumor cells varies from small cells with moderately hyperchromatic, regular nuclei to large cells with large, irregular, hyperchromatic nuclei.
</gallery>
 
== Virtual Microscopy ==
=== Infiltrating Ductal Carcinoma ===
<peir-vm>IPLab7IDC</peir-vm>
 
=== Normal Breast ===
<peir-vm>IPLab7IDC_Normal_Breast</peir-vm>
== Study Questions ==

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