809
edits
Changes
→Virtual Microscopy
File:IPLab2Atrophy10.jpg|This gross photograph shows a normal brain (left) and a brain from a geriatric patient (right). Note the decreased size, the narrowed gyri, and the widened sulci of the brain from this octogenarian. What is the cause of atrophy in this case?
</gallery>
== Virtual Microscopy ==
=== Testis: Atrophy ===
<peir-vm>IPLab2Atrophy</peir-vm>
===Normal Testis ===
<peir-vm>UAB-Histology-00045</peir-vm>
== Study Questions ==
Prostatic growth is dependent upon testicular androgens. Estrogen therapy leads to inhibition of pituitary gonadotropin and/or ACTH production which causes androgen deprivation. Newer drugs use specific testosterone receptor blocking mechanisms to regress prostate hyperplasia and prostate cancer.</spoiler>
* <spoiler text="There appears to be an increase in the number of interstitial cells. Is there such a thing as Leydig cell hyperplasia?">No. The Leydig cells appear more prominent due to the paucity of germ cells.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://www.cancer.gov/cancertopics/pdq/treatment/prostate/HealthProfessional/page3 National Cancer Institute: Prostate Cancer Treatment]
* [http://emedicine.medscape.com/article/457394-overview eMedicine Medical Library: Prostate-Specific Antigen]
* [http://emedicine.medscape.com/article/1967731-overview eMedicine Medical Library: Prostate Cancer]
* [http://www.merckmanuals.com/professional/genitourinary_disorders/genitourinary_cancer/prostate_cancer.html Merck Manual: Prostate Cancer]
=== Journal Articles ===
* van Leenders GJ, Schalken JA. [http://www.ncbi.nlm.nih.gov/pubmed/11589668 Stem cell differentiation within the human prostate epithelium: implications for prostate carcinogenesis]. ''BJU Int'' 2001 Sep;88 Suppl 2:35-42; discussion 49-50.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/146-prostate/219-adenocarcinoma PEIR Digital Library: Prostatic Adenocarcinoma Images]
* [http://library.med.utah.edu/WebPath/MALEHTML/MALEIDX.html WebPath: Male Genital Pathology Images]
{{IPLab 2}}
[[Category: IPLab:Lab 2]]
