Difference between revisions of "IPLab:Lab 10:Histoplasmosis"

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== Clinical Summary ==
 
== Clinical Summary ==
  
For four months before death, this two-year-old black female infant ate poorly and lost weight. When hospitalized, she appeared chronically ill with signs of infection. An exploratory laparotomy showed the patient had enormously enlarged abdominal lymph nodes, the biopsy of which disclosed active histoplasmosis. Despite intensive therapy, the patient died three weeks after admission.  
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For four months before death, this two-year-old black female infant ate poorly and lost weight. When hospitalized, she appeared chronically ill with signs of infection. An exploratory laparotomy showed the patient had enormously enlarged abdominal lymph nodes, the biopsy of which disclosed active histoplasmosis. Despite intensive therapy, the patient died three weeks after admission.
  
== Autopsy Findings ==
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Autopsy showed widespread enlargement of lymph nodes, ulcers of the intestines, and enlarged adrenal glands exhibiting multifocal granulomas.
 
 
Autopsy showed widespread enlargement of lymph nodes, ulcers of the intestines, and enlarged adrenal glands exhibiting multifocal granulomas.  
 
  
 
== Images ==
 
== Images ==
 
<gallery heights="250px" widths="250px">
 
<gallery heights="250px" widths="250px">
File:IPLab10Histo1.jpg|This low-power photomicrograph shows a section of adrenal gland with several irregularly-outlined areas of necrosis.  
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File:IPLab10Histo1b.jpg|This low-power photomicrograph shows a section of adrenal gland with several irregularly-outlined areas of necrosis.  
 
File:IPLab10Histo2.jpg|This higher-power photomicrograph of the previous adrenal gland shows more clearly the irregularly-shaped area of necrosis (arrows).  
 
File:IPLab10Histo2.jpg|This higher-power photomicrograph of the previous adrenal gland shows more clearly the irregularly-shaped area of necrosis (arrows).  
 
File:IPLab10Histo3.jpg|This is an even higher-power photomicrograph of an area of necrosis (arrows). There is loss of cellular detail within this area. There are inflammatory cells present; however, it is difficult to differentiate the inflammatory cells from the native lymphocytes of the adrenal gland--which is a lymph node.  
 
File:IPLab10Histo3.jpg|This is an even higher-power photomicrograph of an area of necrosis (arrows). There is loss of cellular detail within this area. There are inflammatory cells present; however, it is difficult to differentiate the inflammatory cells from the native lymphocytes of the adrenal gland--which is a lymph node.  
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File:IPLab10Histo7.jpg|This photomicrograph was taken under oil immersion to show the silver-stained Histoplasma organisms. Some of the organisms appear to be budding (arrows).  
 
File:IPLab10Histo7.jpg|This photomicrograph was taken under oil immersion to show the silver-stained Histoplasma organisms. Some of the organisms appear to be budding (arrows).  
 
</gallery>
 
</gallery>
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== Virtual Microscopy ==
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=== H&E ===
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<peir-vm>IPLab10Histo_HE</peir-vm>
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=== GMS ===
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<peir-vm>IPLab10Histo_GMS</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==

Latest revision as of 21:53, 9 July 2020

Clinical Summary[edit]

For four months before death, this two-year-old black female infant ate poorly and lost weight. When hospitalized, she appeared chronically ill with signs of infection. An exploratory laparotomy showed the patient had enormously enlarged abdominal lymph nodes, the biopsy of which disclosed active histoplasmosis. Despite intensive therapy, the patient died three weeks after admission.

Autopsy showed widespread enlargement of lymph nodes, ulcers of the intestines, and enlarged adrenal glands exhibiting multifocal granulomas.

Images[edit]

Virtual Microscopy[edit]

H&E[edit]

GMS[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

An infiltrate is an accumulation of cells in the lung parenchyma--this is a sign of pneumonia.