Difference between revisions of "IPLab:Lab 10:Candidiasis"

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== Clinical Summary ==
 
== Clinical Summary ==
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This 73-year-old black male was in good health until about three months before his death when he noticed enlarged lymph nodes first in both inguinal regions and later elsewhere. Antileukemic therapy was begun. About two weeks prior to his death the patient presented to the emergency room with uncontrollable epistaxis. On physical examination, the liver was palpable but the spleen was not. The white blood count was below normal and consisted mainly of lymphocytes with many atypical cells. The patient's bone marrow was also found to be heavily loaded with lymphocytes. Platelets were extremely low and remained so despite platelet transfusions. Subsequently, the patient developed pneumonia which progressed until death. Antemortem cultures yielded Candida tropicalis and Pseudomonas aeruginosa.
  
This 73-year-old black male was in good health until about three months before his death when he noticed enlarged lymph nodes first in both inguinal regions and later elsewhere. Antileukemic therapy was begun. About two weeks prior to his death the patient presented to the emergency room with uncontrollable epistaxis. On physical examination, the liver was palpable but the spleen was not. The white blood count was below normal and consisted mainly of lymphocytes with many atypical cells. The patient's bone marrow was also found to be heavily loaded with lymphocytes. Platelets were extremely low and remained so despite platelet transfusions. Subsequently, the patient developed pneumonia which progressed until death. Antemortem cultures yielded Candida tropicalis and Pseudomonas aeruginosa.
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At autopsy, there was evidence of disseminated candidiasis.
 
 
== Autopsy Findings ==
 
 
 
At autopsy, there was evidence of disseminated candidiasis.  
 
  
 
== Images ==
 
== Images ==
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File:IPLab10Candidiasis8.jpg|This is a higher-power photomicrograph of a Candida colony in the kidney. Note the pseudohyphae of the Candida organisms.  
 
File:IPLab10Candidiasis8.jpg|This is a higher-power photomicrograph of a Candida colony in the kidney. Note the pseudohyphae of the Candida organisms.  
 
</gallery>
 
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== Virtual Microscopy ==
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<peir-vm>IPLab10Candidiasis</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==
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=== Journal Articles ===
 
=== Journal Articles ===
 
* Marr KA, Bowden RA.  [http://www.ncbi.nlm.nih.gov/pubmed/11428995 Fungal infections in patients undergoing blood and marrow transplantation].  ''Transpl Infect Dis'' 1999 Dec;1(4):237-46.
 
* Marr KA, Bowden RA.  [http://www.ncbi.nlm.nih.gov/pubmed/11428995 Fungal infections in patients undergoing blood and marrow transplantation].  ''Transpl Infect Dis'' 1999 Dec;1(4):237-46.
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* Marr KA, Bowden RA.  [http://www.nejm.org/doi/full/10.1056/NEJMra1315399 Invasive Candidiasis].  ''NEJM'' 2015 Oct 8;373:1445-1456.
  
 
=== Images ===
 
=== Images ===

Latest revision as of 21:45, 9 July 2020

Clinical Summary[edit]

This 73-year-old black male was in good health until about three months before his death when he noticed enlarged lymph nodes first in both inguinal regions and later elsewhere. Antileukemic therapy was begun. About two weeks prior to his death the patient presented to the emergency room with uncontrollable epistaxis. On physical examination, the liver was palpable but the spleen was not. The white blood count was below normal and consisted mainly of lymphocytes with many atypical cells. The patient's bone marrow was also found to be heavily loaded with lymphocytes. Platelets were extremely low and remained so despite platelet transfusions. Subsequently, the patient developed pneumonia which progressed until death. Antemortem cultures yielded Candida tropicalis and Pseudomonas aeruginosa.

At autopsy, there was evidence of disseminated candidiasis.

Images[edit]

Virtual Microscopy[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

Epistaxis is bleeding from the nose.

In alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents.