Difference between revisions of "IPLab:Lab 10:Blastomycosis"

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== Clinical Summary ==
 
== Clinical Summary ==
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About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.
  
About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.
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At autopsy the both lungs had areas of consolidation and necrosis.
 
 
== Autopsy Findings ==
 
 
 
Autopsy confirmed that the entire left lung was semi-solid.  
 
  
 
== Images ==
 
== Images ==
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File:IPLab10Blasto10.jpg|This is a very high-power photomicrograph showing Blastomyces organisms stained with PAS. Note the budding organism (arrow) and the underlying pyogranulomatous inflammatory reaction in the background.  
 
File:IPLab10Blasto10.jpg|This is a very high-power photomicrograph showing Blastomyces organisms stained with PAS. Note the budding organism (arrow) and the underlying pyogranulomatous inflammatory reaction in the background.  
 
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== Virtual Microscopy ==
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=== H&E ===
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<peir-vm>IPLab10Blasto_HE</peir-vm>
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=== PAS ===
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<peir-vm>IPLab10Blasto_PAS</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==

Latest revision as of 21:57, 9 July 2020

Clinical Summary[edit]

About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.

At autopsy the both lungs had areas of consolidation and necrosis.

Images[edit]

Virtual Microscopy[edit]

H&E[edit]

PAS[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

In alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents.