Difference between revisions of "IPLab:Lab 10:Blastomycosis"

From Pathology Education Instructional Resource
Jump to: navigation, search
(Clinical Summary)
 
(10 intermediate revisions by 2 users not shown)
Line 1: Line 1:
 
== Clinical Summary ==
 
== Clinical Summary ==
 +
About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.
  
About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.
+
At autopsy the both lungs had areas of consolidation and necrosis.
 
 
== Autopsy Findings ==
 
 
 
Autopsy confirmed that the entire left lung was semi-solid.  
 
  
 
== Images ==
 
== Images ==
Line 20: Line 17:
 
File:IPLab10Blasto10.jpg|This is a very high-power photomicrograph showing Blastomyces organisms stained with PAS. Note the budding organism (arrow) and the underlying pyogranulomatous inflammatory reaction in the background.  
 
File:IPLab10Blasto10.jpg|This is a very high-power photomicrograph showing Blastomyces organisms stained with PAS. Note the budding organism (arrow) and the underlying pyogranulomatous inflammatory reaction in the background.  
 
</gallery>
 
</gallery>
 +
 +
== Virtual Microscopy ==
 +
=== H&E ===
 +
<peir-vm>IPLab10Blasto_HE</peir-vm>
 +
 +
=== PAS ===
 +
<peir-vm>IPLab10Blasto_PAS</peir-vm>
  
 
== Study Questions ==
 
== Study Questions ==
Line 29: Line 33:
 
== Additional Resources ==
 
== Additional Resources ==
 
=== Reference ===
 
=== Reference ===
 
+
* [http://emedicine.medscape.com/article/354067-overview eMedicine Medical Library: Imaging in Thoracic Blastomycosis]
 +
* [http://emedicine.medscape.com/article/296870-overview eMedicine Medical Library: Blastomycosis]
 +
* [http://www.merckmanuals.com/professional/infectious_diseases/fungi/blastomycosis.html Merck Manual: Blastomycosis]
  
 
=== Journal Articles ===
 
=== Journal Articles ===
 
+
* Rooney PJ, Klein BS.  [http://www.ncbi.nlm.nih.gov/pubmed/11906450 Linking fungal morphogenesis with virulence].  ''Cell Microbiol'' 2002 Mar;4(3):127-37.
  
 
=== Images ===
 
=== Images ===
 
+
* [{{SERVER}}/library/index.php?/tags/542-blastomycosis PEIR Digital Library: Blastomycosis Images]
 
+
* [http://library.med.utah.edu/WebPath/INFEHTML/INFECIDX.html Webpath: Infection]
== Related IPLab Cases ==
 
 
 
  
 
{{IPLab 10}}
 
{{IPLab 10}}
  
 
[[Category: IPLab:Lab 10]]
 
[[Category: IPLab:Lab 10]]

Latest revision as of 21:57, 9 July 2020

Clinical Summary[edit]

About three weeks before his death, this 17-year-old white male developed a "chest cold" which gradually worsened. The patient was eventually admitted three days before his death. At that time, the patient was very dyspneic. Chest x-ray showed consolidation of the entire left lung. The initial impression by his care team was staphylococcal pneumonia. However, Blastomyces dermatitides was identified in stained smears of sputum the next day. In spite of appropriate antifungal therapy, the patient deteriorated rapidly and died.

At autopsy the both lungs had areas of consolidation and necrosis.

Images[edit]

Virtual Microscopy[edit]

H&E[edit]

PAS[edit]

Study Questions[edit]


Additional Resources[edit]

Reference[edit]

Journal Articles[edit]

Images[edit]

In alcoholics, aspiration pneumonia is common--bacteria enter the lung via aspiration of gastric contents.