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===Cytology===
* '''Positive for malignancy, the differential diagnosis includes melanoma and Hodgkin lymphoma'''.
===Biopsy===
<gallery heights="250px" widths="250px">
CytologicallyYoursCoW20131202Biopsy1.jpg|20x magnification of lymph node core biopsy.
CytologicallyYoursCoW20131202Biopsy2.jpg|40x magnification of lymph node core biopsy.
CytologicallyYoursCoW20131202Biopsy3.jpg|CD 15 with membranous staining.
CytologicallyYoursCoW20131202Biopsy4.jpg|CD 30 with membranous staining.
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===Biopsy Diagnosis===
* '''Classical Hodgkin lymphoma, favor mixed type'''.
** CD15 Positive in tumor cells
** CD30 Positive in tumor cells
** PAX5 Weakly positive
** CD20 Positive in background lymphocytes
** CD3 Positive in background lymphocytes
** S100 Negative
** Mart1 Negative
** HMB45 Negative
===Discussion===
The features of Hodgkin lymphoma include atypical (Hodgkin cells) and Reed-Sternberg cells. The nucleus should be 3-4x the size of a small lymphocyte. In classic Hodgkin lymphoma, scattered eosinophils, plasma cells, histiocytes, and a predominately CD3+ lymphocyte population will be seen in the background. The immunophenotype of classic Hodgkin lymphoma shows CD15, CD30, MUM1, and weak PAX5 positivity. Histology is usually needed to subtype Hodgkin lymphoma.
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