Cytologically Yours: Unknowns: 201311: Case 4
Clinical History
57 year old female with hypoechoic nodule on ultrasound.
Cytology
Resident Questions
- <spoiler text="Diagnosis?">
- Medullary carcinoma. </spoiler>
- <spoiler text="What syndrome is associated with this entity?">
- MEN 2A and MEN 2B.
- 80-90% are sporadic </spoiler>
- <spoiler text="What are the immunohistochemical features?">
- Immunoreactivity with CEA, TTF1, calcitonin, chromogranin, synaptophysin.
- Negative immunoreactivity with thyroglobulin </spoiler>
- <spoiler text="What extracellular material may be associated with this neoplasm?">
- Amyloid.</spoiler>