Cytologically Yours: Unknowns: 201311: Case 3: Difference between revisions
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* <spoiler text="What other entities of the thyroid may exhibit intranuclear pseudoinclusions?"> | * <spoiler text="What other entities of the thyroid may exhibit intranuclear pseudoinclusions?"> | ||
*Medullary carcinoma. </spoiler> | *Medullary carcinoma. </spoiler> | ||
==Cytologic Features== | |||
*Powdery chromatin, grooves, pseudoinclusions, nucleolus | |||
*Crowding and overlapping | |||
*Sheets, papillae | |||
*Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated) | |||
*Psammoma bodies | |||
*Giant cells | |||
*Bubble gum colloid | |||
*Septated cytoplasm | |||
Latest revision as of 19:54, 10 January 2014
Clinical History
32 year old male with a solid thyroid nodule on ultrasound.
Cytology
Resident Questions
- <spoiler text="Diagnosis?">
- Papillary carcinoma. </spoiler>
- <spoiler text="What are the most common molecular associations?">
- Rearrangements of Ret proto-oncogene on Chromosome 10 (RET/PTC).
- Point mutations of BRAF and RAS </spoiler>
- <spoiler text="What other entities of the thyroid may exhibit intranuclear pseudoinclusions?">
- Medullary carcinoma. </spoiler>
Cytologic Features
- Powdery chromatin, grooves, pseudoinclusions, nucleolus
- Crowding and overlapping
- Sheets, papillae
- Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated)
- Psammoma bodies
- Giant cells
- Bubble gum colloid
- Septated cytoplasm