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→Clinical Summary
== Clinical Summary ==
This male fetus of a 21-year-old Rh-positive mother (Gravida 2 Para 1011) was the product of an induced delivery at 21 weeks gestation. At 19 weeks gestation, routine prenatal examination had revealed a maternal serum alpha-fetoprotein (AFP) level that was 4.2 times the mean for a mother at this point in gestation. A targeted ultrasound was ordered--which revealed a lumbosacral neural tube defect--and an amniocentesis was performed. Amniotic fluid showed an AFP level that was 5.3 times the calculated median value and cytogenetic analysis demonstrated a normal male (46XY) chromosome pattern. The parents requested termination of the pregnancy and a 465-gram male nondysmorphic stillborn fetus was delivered vaginally.
== Images ==
Clinical deficits usually occur in motor and sensory function in the lower extremities as well as disturbances of bowel and bladder control.</spoiler>
== Additional Resources ==
=== Reference ===
* [http://emedicine.medscape.com/article/311113-overview eMedicine Medical Library: Spina Bifida]
* [http://emedicine.medscape.com/article/1825866-overview eMedicine Medical Library: Neural Tube Defects in the Neonatal Period]
* [http://emedicine.medscape.com/article/1177162-overview eMedicine Medical Library: Neural Tube Defects]
* [http://www.merckmanuals.com/professional/special_subjects/general_principles_of_medical_genetics/multifactorial_complex_inheritance.html Merck Manual: Multifactorial (Complex) Inheritance]
* [http://www.merckmanuals.com/professional/pediatrics/congenital_neurologic_anomalies/spina_bifida.html Merck Manual: Spina Bifida]
=== Journal Articles ===
* Cortes RA, Farmer DL. [http://www.ncbi.nlm.nih.gov/pubmed/15283099 Recent advances in fetal surgery]. ''Semin Perinatol'' 2004 Jun;28(3):199-211.
=== Images ===
* [{{SERVER}}/library/index.php?/tags/2173-myelomeningocele PEIR Digital Library: Myelomeningocele Images]
* [http://library.med.utah.edu/WebPath/PEDHTML/PEDIDX.html WebPath: Pediatric-Perinatal Pathology]
{{IPLab 13}}
[[Category: IPLab:Lab 13]]
