Difference between revisions of "Cytologically Yours: CoW: 20140220"

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(Created page with "== Clinical Summary == The patient is a 58 year old male with back and neck pain. === Past Medical History === * Cervical spondylosis * Hypertension * Hyperlipidemia === Pa...")
 
(Cytology)
 
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===Cytology===
 
===Cytology===
 
<gallery heights="250px" widths="250px">
 
<gallery heights="250px" widths="250px">
CytologicallyYoursCoW20140220Cytology1.jpg|40x magnification of highly atypical malignant appearing cells.
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CytologicallyYoursCoW20140220Cytology1.jpg|20x magnification of a cellular specimen with numerous follicles and absent colloid.
CytologicallyYoursCoW20140220Cytology2.jpg|20x magnification showing osteoid formation.
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CytologicallyYoursCoW20140220Cytology2.jpg|40x magnification with follicular cells forming microfollicular groups and inspissated colloid.
CytologicallyYoursCoW20140220Cytology3.jpg|40x magnification showing osteoid formation and malignant appearing cells.
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CytologicallyYoursCoW20140220Cytology3.jpg|60x magnification with follicular cells forming microfollicular groups and inspissated colloid. Nuclear are crowded with overlapping. The nuclei are enlarged.
CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification showing osteoid formation and malignant appearing cells.
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CytologicallyYoursCoW20140220Cytology4.jpg|40x magnification with follicular cells forming a microfollicular group and inspissated colloid.
CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of osteoid.
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CytologicallyYoursCoW20140220Cytology5.jpg|40x magnification of Pap stained material showing magnification with follicular cells forming microfollicular groups and inspissated colloid..
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CytologicallyYoursCoW20140220Cytology6.jpg|60x magnification of Pap stained material with microfollicles.
  
 
</gallery>
 
</gallery>
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====Resident Questions====
 
====Resident Questions====
 
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma.  </spoiler>
 
* <spoiler text="What is the differential diagnosis?"> In a cellular thyroid lesion, follicular neoplasm, including adenoma and carcinoma, and cellular benign follicular nodule are in the differential. Also in the differential is the follicular variant of papillary carcinoma.  </spoiler>
* <spoiler text="What are the molecular features that differentiate follicular carcinoma and papillary carcinoma?>"> Follicular carcinoma show PAX8-PPAR gamma translocations and papillary carcinoma shows BRAF mutations and RET/PTC rearrangements. </spoiler>
 
  
 
<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer">Click here to toggle the diagnosis and discussion.</div>
 
<div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer">Click here to toggle the diagnosis and discussion.</div>

Latest revision as of 22:47, 4 March 2014

Clinical Summary

The patient is a 58 year old male with back and neck pain.

Past Medical History

  • Cervical spondylosis
  • Hypertension
  • Hyperlipidemia

Past Surgical History

  • No surgical history

Radiology

  • Ultrasound of the neck shows a solid interpolar nodule 1.8 x 1.6 cm in the left lobe of the thyroid.

Clinical Plan

Fine needle aspiration of the nodule is scheduled.

Pathology

Cytology


Resident Questions


Click here to toggle the diagnosis and discussion.