Difference between revisions of "Cytologically Yours: CoW: 20131209"
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* <spoiler text="What are other immunohistochemical stains that would be applicable in this case?"> | * <spoiler text="What are other immunohistochemical stains that would be applicable in this case?"> | ||
| − | ** RCC | + | ** RCC |
| − | ** CD10 | + | ** CD10 |
| − | ** PAX2 | + | ** PAX2 |
| − | ** Kidney specific antigen | + | ** Kidney specific antigen |
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Revision as of 21:16, 14 January 2014
Contents
Clinical Summary
The patient is an 64 year old white male who presented with left sided back pain. Imaging showed a left perinephric retroperitoneal hematoma and a left renal lower pole cystic lesion with hemorrhage. Additional imaging showed numerous pulmonary lesions. A endobronchial ultrasound guided fine needle aspiration was scheduled.
Past Medical History
- Congestive heart failure
- Ventricular tachycardia
- Ischemic heart disease
Past Surgical History
- Coronary stent placement
- Implant of AICD
Clinical Plan
The concern is a primary renal malignancy with metastatic disease to lungs. An endobronchial ultrasound guided FNA is scheduled. An onsite rapid diagnosis by cytology was scheduled.
Radiology
- CT Abdomen shows a large perinephric hematoma and large low anterior structure in left lower pole suspicious for a hemorrhagic renal cell carcinoma.
- CT Chest shows multiple small lung lesions measuring up to 13x12 mm in greatest dimension.
Pathology
Cytology
4x magnification of a 4R lymph node. Groups of cohesive epithelial appearing cells can be seen on low power. Lymphoid tissue is not easily identified.
20x magnification of a 4R lymph node. This is a cellular specimen with groups of cells along what appear to be a papillary or papillary-like structure. Single cells are also dispersed in the background. The cells are haphazardly arranged.
40x magnification of a 4R lymph node. On higher power, the nuclei appear mildly atypical and the cytoplasm is delicate and finely vacuolated. The nuclear contours are somewhat irregular.
Cell block of 4R lymph node. The cytoplasm does not appear as vacuolated on alcohol fixed cell block material, but the nuclei are relatively uniform, but somewhat atypical.
Immunohistochemistry
PAX8 on 4R lymph node shows positive nuclear staining.
Resident Questions
Final Diagnosis
Cytology
- Rapid diagnosis: Non-small cell carcinoma.
- Final diagnosis: Renal cell carcinoma.
Case Discussion
This is a classic case of metastatic renal cell carcinoma.
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