Cytologically Yours: Unknowns: 201311: Case 3: Difference between revisions
Jump to navigation
Jump to search
Created page with "==Clinical History== 32 year old male with a solid thyroid nodule on ultrasound. ==Cytology== <gallery heights="250px" widths="250px"> CytologicallyYoursUnknowns201311-2-01.j..." |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 4: | Line 4: | ||
==Cytology== | ==Cytology== | ||
<gallery heights="250px" widths="250px"> | <gallery heights="250px" widths="250px"> | ||
CytologicallyYoursUnknowns201311- | CytologicallyYoursUnknowns201311-3-01.jpg | ||
CytologicallyYoursUnknowns201311- | CytologicallyYoursUnknowns201311-3-02.jpg | ||
CytologicallyYoursUnknowns201311- | CytologicallyYoursUnknowns201311-3-03.jpg | ||
</gallery> | </gallery> | ||
| Line 12: | Line 12: | ||
===Resident Questions=== | ===Resident Questions=== | ||
* <spoiler text="Diagnosis?"> | * <spoiler text="Diagnosis?"> | ||
* | * Papillary carcinoma. </spoiler> | ||
* <spoiler text="What are the most common molecular associations?"> | * <spoiler text="What are the most common molecular associations?"> | ||
* | * Rearrangements of Ret proto-oncogene on Chromosome 10 (RET/PTC). | ||
* | * Point mutations of BRAF and RAS </spoiler> | ||
</spoiler> | * <spoiler text="What other entities of the thyroid may exhibit intranuclear pseudoinclusions?"> | ||
*Medullary carcinoma. </spoiler> | |||
==Cytologic Features== | |||
*Powdery chromatin, grooves, pseudoinclusions, nucleolus | |||
*Crowding and overlapping | |||
*Sheets, papillae | |||
*Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated) | |||
*Psammoma bodies | |||
*Giant cells | |||
*Bubble gum colloid | |||
*Septated cytoplasm | |||
Latest revision as of 19:54, 10 January 2014
Clinical History
32 year old male with a solid thyroid nodule on ultrasound.
Cytology
Resident Questions
- <spoiler text="Diagnosis?">
- Papillary carcinoma. </spoiler>
- <spoiler text="What are the most common molecular associations?">
- Rearrangements of Ret proto-oncogene on Chromosome 10 (RET/PTC).
- Point mutations of BRAF and RAS </spoiler>
- <spoiler text="What other entities of the thyroid may exhibit intranuclear pseudoinclusions?">
- Medullary carcinoma. </spoiler>
Cytologic Features
- Powdery chromatin, grooves, pseudoinclusions, nucleolus
- Crowding and overlapping
- Sheets, papillae
- Variable cytoplasm (scant, squamoid, Hurthle-like, vacuolated)
- Psammoma bodies
- Giant cells
- Bubble gum colloid
- Septated cytoplasm