IPLab:Lab 7:Metastatic Adenocarcinoma

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Contents

Clinical Summary

This 58-year-old male was admitted five weeks earlier with a weight loss of 80 pounds over a six-month period, abdominal cramps, and rebound tenderness in the right lower quadrant. Abdominal and chest x-rays showed multiple nodularNodular hyperplasia of the prostate--characterized by large discrete prostatic nodules--is a common disorder in men over 50 years of age. The nodules cause the prostate to be enlarged and to have an increased weight. The human prostate is surrounded by a restrictive capsule. These nodules cause increased pressure within the capsule which leads to constriction of the urethra as it passes through the prostate. Urethral constriction leads to retention of urine. radiopacities in the lungs and liver. Fine needle biopsy of the liver revealed adenocarcinoma with the primary source thought to be colon. He was discharged on chemotherapy, but returned two days later with small bowel obstruction and sepsis, and he died a few days later.

Autopsy Findings

Autopsy revealed an obstructive firm mass in the cecum with similar masses in the lungs, lymph nodes, liver and peritoneum. A large retrocecal abscessAn abscess is a collection of pus (white blood cells) within a cavity formed by disintegrated tissue. was found. Blood cultures grew Klebsiella pneumoniae and E. coli.

Images

Virtual Microscopy

Lung

Liver

Study Questions


Additional Resources

Reference

Journal Articles

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