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IPLab:Lab 5:Hemochromatosis

Revision as of 19:47, 8 July 2020 by Peter Anderson (talk | contribs) (Clinical Summary)

Contents

Clinical SummaryEdit

This 61-year-old female was first admitted to the hospital because of ascites and pedal edema. A liver biopsy revealed a marked intracellular accumulation of iron. The serum iron concentration was increased at 220 mcg/dL. On the basis of these studies, the diagnosis of hemochromatosis was made. Subsequent to the first admission, the patient was admitted on several occasions for ascites. The patient's last admission was necessitated by the development of symptoms and signs of hepatic failure characterized by jaundice and coma.

At autopsy the liver weighed 800 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.

Autopsy FindingsEdit

The liver weighed 820 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.

ImagesEdit

Virtual MicroscopyEdit

H&EEdit

Liver: HemochromatosisEdit

Normal LiverEdit

Prussian BlueEdit

Study QuestionsEdit


Additional ResourcesEdit

ReferenceEdit

Journal ArticlesEdit

ImagesEdit

Related IPLab CasesEdit

Normal serum iron levels are 35 to 160 micrograms/dL.

Jaundice (or icterus) is a state of hyperbilirubinemia (increased bilirubin in the blood) in which bile pigment is deposited in the skin, mucous membranes, and scleras. This deposition of bile pigment results in a yellow appearance.

The normal weight of the right lung in an adult is 450 grams (range: 360 to 570 grams).

A normal liver weighs 1650 grams (range: 1500 to 1800 grams).

Cirrhosis is a liver disease characterized by necrosis, fibrosis, loss of normal liver architecture, and hyperplastic nodules.