Cytologically Yours: Unknowns: 201311: Case 1: Difference between revisions

Revision as of 15:40, 10 January 2014

45 year old female with hypothyroidism.

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 ===Resident Questions===
-* <spoiler text="Diagnosis?">Lymphocytic thyroiditis (Hashimoto thyroiditis). </spoiler>
+* <spoiler text="Diagnosis?">
+* Lymphocytic thyroiditis (Hashimoto thyroiditis). </spoiler>
 * <spoiler text="What are the clinical findings that support this diagnosis?">
 * The diagnosis of Hashimoto is based on one or more circulating autoantibodies. The most common are anti-thyroglobulin and anti-thyroid peroxidase (TPO).
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-==Additional Teaching Points==
-===Immunohistochemistry===
-* TTF-1 (nuclear stain)
-** Thyroid Transcription factor1 regulates transcription of genes specific to the thyroid, lung, and diencephalon
-** If metastatic thyroid cancer to the lung is ruled out by morphology or +thyroglobulin; then a +TTF1 supports adenocarcinoma originating from the lung
-* P63 (nuclear stain) and 34BE12 (cytoplasmic stain)
-** Used for squamous differentiation
-* TTF1 is more sensitive than p63
-** If a tumor stains for both it is more likely to be adenocarcinoma
-* Napsin A(cytoplasmic stain)
-** Granular staining pattern
-** Marker for adenocarcinoma
 {{Cytologically Yours}}