CRP-35: Difference between revisions
Created page with "'''CRP-35''' ==Clinical History== ==Gross Description:== ==Pathology== ===Case CRP-035 H&E=== <peir-vm>specialcrp/CRP-035_HE</peir-vm> ===Case CRP-035 PASH=== <peir-vm>specialcrp/CRP-035_PASH</peir-vm> ===Case CRP-035 IHC=== <peir-vm>specialcrp/CRP-035_IHC</peir-vm> ===Case CRP-035 IHC_control=== <peir-vm>specialcrp/CRP-035_IHC_control</peir-vm> <div class="usermessage mw-customtoggle-diagnosis" style="cursor:pointer"> Microscopic Description, Immunofluorescence, and..." |
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'''CRP-35''' | '''CRP-35''' | ||
==Clinical History== | ==Clinical History== | ||
The patient is a 25 year old female who is status post renal transplant two years ago. She presents for explant nephrectomy due to rejection. | |||
==Gross Description | ==Gross Description== | ||
The specimen is received in a container labeled with the patient's name, medical record number and “transplant nephrectomy”. Received in saline solution is a fragmented and distorted nephrectomy specimen that weighs in aggregate 250 grams and measures 15 x 8 x 4 cm in greatest dimension. The kidney is externally covered by a tan-pink shiny capsule with areas of petechial hemorrhages. This capsule strips with ease, revealing a red-brown granular external surface. The cut surface is pale tan with congestion. The cortico-medullary junction cannot be grossly identified and the portion of pelvico-calyceal system that can be grossly identified, is lined by a tan-white smooth glistening and congested mucosa. No gross lesions are present. The specimen is submitted in four cassettes. | |||
==Pathology== | ==Pathology== | ||
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<div class="mw-collapsible-content"> | <div class="mw-collapsible-content"> | ||
==Microscopic Description | ==Microscopic Description== | ||
===Light Microscopy | ===Light Microscopy=== | ||
A1-A4 – Sections through transplant kidney. A microscopic examination has been performed. | |||
===Immunofluorescence=== | |||
IHC-CD68 | |||
</div></div> | </div></div> | ||
<spoiler text="Diagnosis and Comments"> | <spoiler text="Diagnosis and Comments"> | ||
Kidney, transplant nephrectomy – Malakoplakia | |||
- Moderately severe chronic vascular rejection and acute vascular rejection | |||
- Acute tubulitis. | |||
- Tubular atrophy and interstitial fibrosis | |||
Much of the renal parenchyma is replaced by sheets of large eosinophilic macrophages with occasional small round structures in their cytoplasm, consistent with Michaelis-Guttman bodies. These macrophages stain strongly with CD68 and are negative for cytokeratin. The stains for fungal organisms, acid fast bacilli and Whipples bacteria are negative. | |||
</spoiler> | </spoiler> | ||
Revision as of 08:10, 8 October 2026
CRP-35
Clinical History
The patient is a 25 year old female who is status post renal transplant two years ago. She presents for explant nephrectomy due to rejection.
Gross Description
The specimen is received in a container labeled with the patient's name, medical record number and “transplant nephrectomy”. Received in saline solution is a fragmented and distorted nephrectomy specimen that weighs in aggregate 250 grams and measures 15 x 8 x 4 cm in greatest dimension. The kidney is externally covered by a tan-pink shiny capsule with areas of petechial hemorrhages. This capsule strips with ease, revealing a red-brown granular external surface. The cut surface is pale tan with congestion. The cortico-medullary junction cannot be grossly identified and the portion of pelvico-calyceal system that can be grossly identified, is lined by a tan-white smooth glistening and congested mucosa. No gross lesions are present. The specimen is submitted in four cassettes.
Pathology
Case CRP-035 H&E
Case CRP-035 PASH
Case CRP-035 IHC
Case CRP-035 IHC_control
Microscopic Description
Light Microscopy
A1-A4 – Sections through transplant kidney. A microscopic examination has been performed.
Immunofluorescence
IHC-CD68