IPLab:Lab 5:Hemochromatosis: Difference between revisions - Pathology Education Instructional Resource

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At autopsy the liver weighed 800 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.

~~== Autopsy Findings ==~~

~~The liver weighed 820 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.~~

== Images ==

File:~~IPLab5Hemochromatosis1~~.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.

File:IPLab5Hemochromatosis1b.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.

File:~~IPLab5Hemochromatosis2~~.jpg|This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).

File:IPLab5Hemochromatosis2b.jpg|This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).

File:~~IPLab5Hemochromatosis3~~.jpg|This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).

File:IPLab5Hemochromatosis3b.jpg|This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).

File:IPLab5Hemochromatosis4.jpg|This higher-power view of liver from this case demonstrates the nodules and the brown/black pigment within liver parenchymal cells (arrows).

File:IPLab5Hemochromatosis5.jpg|This higher-power photomicrograph demonstrates the increased fibrosis in the periportal area (1) and the pigment accumulation (2).

File:IPLab5Hemochromatosis6.jpg|This trichrome stain of liver section demonstrates the increased fibrous connective tissue in this liver. Note that the liver nodules (1) are surrounded by fibrous connective tissue (2).

File:~~IPLab5Hemochromatosis7~~.jpg|This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.

File:IPLab5Hemochromatosis7b.jpg|This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.

File:IPLab5Hemochromatosis8.jpg|This higher-power view of liver stained with Prussian blue demonstrates the marked accumulation of iron within the parenchymal cells (1) and in the Kupffer cells in the periportal area (2).

File:IPLab5Hemochromatosis9.jpg|This is a gross picture of pancreas from this case. Note the brown discoloration of the tissue.

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 At autopsy the liver weighed 800 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.
-== Autopsy Findings ==
-The liver weighed 820 grams. The cut surface was described as golden-brown in color, having a fine, diffuse nodularity, and being extremely firm in consistency.
 == Images ==
 <gallery heights="250px" widths="250px">
-File:IPLab5Hemochromatosis1.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.
+File:IPLab5Hemochromatosis1b.jpg|This is a gross photograph of liver (1) and pancreas (2) from this case of hemochromatosis. Note that both of these organs have a dark brown coloration.
-File:IPLab5Hemochromatosis2.jpg|This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).
+File:IPLab5Hemochromatosis2b.jpg|This is a gross photograph of a cut section of liver from this case of hemochromatosis. Note that the liver is dark brown. Although hard to appreciate in a photograph, the tissue is also firm (cirrhotic).
-File:IPLab5Hemochromatosis3.jpg|This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).
+File:IPLab5Hemochromatosis3b.jpg|This is a low-power micrograph of liver from this patient. Note the nodularity of the tissue (arrows).
 File:IPLab5Hemochromatosis4.jpg|This higher-power view of liver from this case demonstrates the nodules and the brown/black pigment within liver parenchymal cells (arrows).
 File:IPLab5Hemochromatosis5.jpg|This higher-power photomicrograph demonstrates the increased fibrosis in the periportal area (1) and the pigment accumulation (2).
 File:IPLab5Hemochromatosis6.jpg|This trichrome stain of liver section demonstrates the increased fibrous connective tissue in this liver. Note that the liver nodules (1) are surrounded by fibrous connective tissue (2).
-File:IPLab5Hemochromatosis7.jpg|This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.
+File:IPLab5Hemochromatosis7b.jpg|This is a low-power view of liver section stained with Prussian blue. Prussian blue reacts with iron in the tissue to give a blue color.
 File:IPLab5Hemochromatosis8.jpg|This higher-power view of liver stained with Prussian blue demonstrates the marked accumulation of iron within the parenchymal cells (1) and in the Kupffer cells in the periportal area (2).
 File:IPLab5Hemochromatosis9.jpg|This is a gross picture of pancreas from this case. Note the brown discoloration of the tissue.