IPLab:Lab 2:Hyperplasia: Difference between revisions - Pathology Education Instructional Resource

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== Clinical Summary ==

This 87-year-old man ~~dated the onset~~ of ~~his illness to approximately six months prior to admission at which time he noted~~ difficulty in starting his urine stream. He was seen several times in the emergency room for acute urinary retention and dysuria. On several occasions, significant numbers of white blood cells and bacteria (suggestive of acute cystitis) were noted in the patient's urine specimen.

This 87-year-old man has had a three year history of difficulty in starting his urine stream. He was seen several times in the emergency room for acute urinary retention and dysuria. On several occasions, significant numbers of white blood cells and bacteria (suggestive of acute cystitis) were noted in the patient's urine specimen.

Terminally, the patient developed fever, confusion that progressed to coma, convulsions, and shock. At the time of his death, the patient's major clinical problem was Gram-negative sepsis secondary to a urinary tract infection.

~~== Autopsy Findings ==~~

At autopsy the prostate gland was grossly enlarged (6.5 x 4.8 x 3.2 cm) and weighed 75 grams. The prostate gland was nodular but the nodules were confined within the prostatic capsule.

== Images ==

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File:IPLab2Hyperplasia3.jpg|This is a low-power photomicrograph showing hyperplastic prostate on the left (1) and normal prostate on the right (2). At this power, dilated glands are visible in the section of hyperplastic prostate.

File:IPLab2Hyperplasia4.jpg|The dilated glands (arrows) make up the major portion of the prostate tissue and there is compression of the stroma.

File:IPLab2Hyperplasia5.jpg|Note these glands, which exhibit hyperplasia of the glandular epithelium. The infolding of the glandular epithelial cells forms papillary projections (arrows) into the lumen of the gland.

File:IPLab2Hyperplasia6.jpg|Cystic dilatation of glands is present in this photomicrograph. Notice the accumulation of secretory material inside the glands (arrows) and compression (thinning) of the lining epithelium.

File:IPLab2Hyperplasia7.jpg|A higher-power view shows the papillary folds (arrows) produced by the hyperplastic epithelium projecting into the lumen of the gland. While these papillary folds project into the lumen of the gland, there is no extension through the glandular basement membrane into the gland's stroma.

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=== Normal Prostate ===

<peir-vm>~~IPlab2Hyperplasia_normal_Prostate~~</peir-vm>

<peir-vm>IPLab2Hyperplasia_normal_Prostate</peir-vm>

== Study Questions ==

@@ Line 1: / Line 1: @@
 == Clinical Summary ==
-This 87-year-old man dated the onset of his illness to approximately six months prior to admission at which time he noted difficulty in starting his urine stream. He was seen several times in the emergency room for acute urinary retention and dysuria. On several occasions, significant numbers of white blood cells and bacteria (suggestive of acute cystitis) were noted in the patient's urine specimen.
+This 87-year-old man has had a three year history of difficulty in starting his urine stream. He was seen several times in the emergency room for acute urinary retention and dysuria. On several occasions, significant numbers of white blood cells and bacteria (suggestive of acute cystitis) were noted in the patient's urine specimen.
 Terminally, the patient developed fever, confusion that progressed to coma, convulsions, and shock. At the time of his death, the patient's major clinical problem was Gram-negative sepsis secondary to a urinary tract infection.
-== Autopsy Findings ==
+At autopsy the prostate gland was grossly enlarged (6.5 x 4.8 x 3.2 cm) and weighed 75 grams. The prostate gland was nodular but the nodules were confined within the prostatic capsule.
-At autopsy the prostate gland was grossly enlarged (6.5 x 4.8 x 3.2 cm) and weighed 75 grams. The prostate gland was nodular but the nodules were confined within the prostatic capsule.
 == Images ==
@@ Line 13: / Line 12: @@
 File:IPLab2Hyperplasia3.jpg|This is a low-power photomicrograph showing hyperplastic prostate on the left (1) and normal prostate on the right (2). At this power, dilated glands are visible in the section of hyperplastic prostate.
 File:IPLab2Hyperplasia4.jpg|The dilated glands (arrows) make up the major portion of the prostate tissue and there is compression of the stroma.
-File:IPLab2Hyperplasia5.jpg|Note these glands, which exhibit hyperplasia of the glandular epithelium. The infolding of the glandular epithelial cells forms papillary projections (arrows) into the lumen of the gland.
 File:IPLab2Hyperplasia6.jpg|Cystic dilatation of glands is present in this photomicrograph. Notice the accumulation of secretory material inside the glands (arrows) and compression (thinning) of the lining epithelium.
 File:IPLab2Hyperplasia7.jpg|A higher-power view shows the papillary folds (arrows) produced by the hyperplastic epithelium projecting into the lumen of the gland. While these papillary folds project into the lumen of the gland, there is no extension through the glandular basement membrane into the gland's stroma.
@@ Line 25: / Line 23: @@
 === Normal Prostate ===
-<peir-vm>IPlab2Hyperplasia_normal_Prostate</peir-vm>
+<peir-vm>IPLab2Hyperplasia_normal_Prostate</peir-vm>
 == Study Questions ==